Reliability of voxel values from cone-beam computed tomography for dental use in evaluating bone mineral density
Reliability of voxel values from cone-beam computed tomography for dental use in evaluating bone mineral density
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DOI：
10.1111/j.1600-0501.2009.01896.x
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发表时间：
2010-05-01
影响因子：
4.3
通讯作者：
Kurabayashi, Tohru
中科院分区：
文献类型：
--
作者：
Nomura, Yoshikazu;Watanabe, Hiroshi;Kurabayashi, Tohru
目的探讨利用锥形束CT （CBCT）体素值评估牙体骨密度（BMD）的可行性。材料与方法采用CBCT和多层螺旋CT （MSCT）对含有不同浓度碘溶液的铝棒和样管进行水影成像。分别测量样本的体素值和CT数，并分析两者的相关性。此外，根据羟基磷灰石（HA）参考幻像的CT编号，得到体素值与骨密度的转换公式。结果无论x射线剂量或平均能量如何，CBCT体素值与溶液中的碘浓度呈正相关，但在较高的碘浓度下，体素值有轻微的饱和趋势。体素值和CT数之间也有很好的相关性。回归分析表明，非线性（线性二次模型）回归比线性回归拟合更适合绘制这两个值，尽管后者可能可用于临床应用。CBCT体素值与等效骨密度的换算公式为：y=-0.03669x2+3.602x-350.3 （x：体素值，y：骨密度mg/cm3 HA）。结论本研究显示CBCT的体素值与MSCT的CT数有较高的相关性。虽然这是一项体外研究，假设了测量体素值的理想条件，但利用CBCT图像的体素值估计CT数和BMD显然是有可能的，但这种关系并不完全是线性的，应该进一步研究。引用本文：Nomura Y， Watanabe H, Honda E, Kurabayashi T.用锥形束计算机断层扫描体素值评估牙齿骨矿物质密度的可靠性。中华口腔医学杂志，2010；558 - 562。doi: 10.1111 / j.1600-0501.2009.01896.x。
ObjectivesThe aim of this study was to investigate whether it was possible to evaluate bone mineral density (BMD) using voxel values from cone-beam CT (CBCT) for dental use.Materials and methodsA water phantom with an aluminum rod and sample tubes containing iodine solutions of various concentration was imaged by CBCT and multi-slice CT (MSCT). Voxel values and CT numbers, respectively, of the samples were measured and their correlation was investigated. In addition, based on the CT numbers of a hydroxyapatite (HA) reference phantom, a conversion formula from voxel value to BMD was obtained.ResultsThere was a positive correlation between the voxel values of CBCT and the iodine concentration of the solutions, regardless of the X-ray dose or the mean energy, although the voxel values had a slight tendency to be saturated at higher iodine concentrations. An excellent correlation between the voxel values and CT numbers was also observed. A regression analysis showed that nonlinear (linear-quadratic model) regression was more appropriate than linear regression fitting for plotting these two values, although the latter might be usable for clinical applications. The conversion formula from the voxel value of CBCT to the equivalent BMD was as follows: y=-0.03669x2+3.602x-350.3 (x: voxel value, y: BMD mg/cm3 HA).ConclusionsThis study revealed that there was a high correlation between the voxel values of CBCT and the CT numbers of MSCT. Although this was an in vitro study with assumed ideal conditions for measuring voxel values, there was a clear possibility for estimating CT numbers and BMD using the voxel values from the CBCT images, but the relationship was not entirely linear and should be examined further.To cite this article:Nomura Y, Watanabe H, Honda E, Kurabayashi T. Reliability of voxel values from cone-beam computed tomography for dental use in evaluating bone mineral density.Clin Oral Impl Res. 21, 2010; 558-562.doi: 10.1111/j.1600-0501.2009.01896.x.