COMPARISON OF REGENERATION RESULTS OF PREFABRICATED NERVE GRAFT, AUTOGENOUS NERVE GRAFT, AND VEIN GRAFT IN REPAIR OF NERVE DEFECTS
COMPARISON OF REGENERATION RESULTS OF PREFABRICATED NERVE GRAFT, AUTOGENOUS NERVE GRAFT, AND VEIN GRAFT IN REPAIR OF NERVE DEFECTS
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DOI：
10.1002/micr.20586
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发表时间：
2009-01-01
期刊：
影响因子：
2.1
通讯作者：
Celikoz, Bahattin
中科院分区：
文献类型：
--
作者：
Karagoz, Huseyin;Ulkur, Ersin;Celikoz, Bahattin
本研究旨在评价预构神经移植修复神经缺损的效果，并与自体神经移植和静脉移植进行比较。共设四组，每组10只大鼠。首先，在8周内对I组和II组进行神经预构。为此，将颈静脉移植物以端侧方式缝合到右侧腓神经和胫神经上的神经外膜窗。为产生神经营养刺激，I组对神经进行部分切割，II组通过向邻近肌肉注射质粒进行基因治疗。第8周末，取预制的神经移植物、颈静脉和穿过颈静脉的轴突。然后在各组左侧腓总神经上制造间隙。I、II组采用预制神经移植修复腓神经缺损，III组采用自体神经移植修复腓神经缺损，IV组采用静脉移植修复腓神经缺损。随访期后进行形态学评估。从电生理和形态学结果来看，前三组结果相似。三组之间无统计学显著差异。预制神经移植物与自体神经移植物一样有效，可作为自体神经移植物的替代物用于神经缺损的修复。(c)2008 Wiley-Liss，Inc.显微外科29：138-143，2009。
The purpose of this study was to evaluate the effectivity of prefabricated nerve grafts in the repairing nerve defect and to compare them with the autogenous nerve graft and vein graft. Four groups were created, each containing 10 rats. First, nerve prefabrication was carried out in groups I and II during 8 weeks. For this purpose, jugular vein graft was sutured to the epineural windows on the peroneal and tibial nerve at the right side in an end-to-side fashion. To create neurotrophic stimulus, partial incision was performed on the nerves in group I, and gene therapy was performed by plasmid injecting to the adjacent muscles in group II. At the end of the eighth week, prefabricated nerve grafts, jugular vein, and the axons passing through it were taken. Then, gap was created on the left peroneal nerve in all groups. Defect on the peroneal nerve was repaired by using the prefabricated nerve grafts in groups I and II, the autogenous nerve graft in group III, and the vein in group IV Assessment of nerve regeneration was performed by using electromyography. Morphological assessment was performed after follow-up period. According to electrophysiological and morphological results, the results of first three groups were similar. There was no statistically significant difference between three groups. Prefabricated nerve graft is as effective as autogenous nerve graft, and it can be used in the repair of nerve defects as autogenous nerve graft as an alternative. (c) 2008 Wiley-Liss, Inc. Microsurgery 29:138-143, 2009.