Fibrocytes in Asthma and Chronic Obstructive Pulmonary Disease: Variations on the Same Theme
Fibrocytes in Asthma and Chronic Obstructive Pulmonary Disease: Variations on the Same Theme
复制标题
哮喘和慢性阻塞性肺疾病中的纤维细胞：同一主题的变化
DOI：
10.1165/rcmb.2017-0301ps
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发表时间：
2018-03-01
影响因子：
6.4
通讯作者：
Berger, Patrick
中科院分区：
文献类型：
--
作者：
Dupin, Isabelle;Contin-Bordes, Cecile;Berger, Patrick
纤维细胞是具有成纤维细胞特性的循环细胞。它们由骨髓基质产生，并通过多种趋化因子途径从血液转移到受损器官。它们在响应局部组织微环境时表现出显著的功能和表型可塑性，以确保促炎或更消退的表型。它们可以采用免疫细胞特性并调节常规免疫细胞功能。虽然它们的确切功能并不总是清楚的，但它们已成为几种纤维化疾病如瘢痕疙瘩、硬皮病和特发性肺纤维化中的关键效应细胞。最近的证据表明，纤维细胞可能有助于支气管阻塞性疾病，如哮喘和慢性阻塞性肺疾病。本文综述了纤维细胞及其途径在哮喘和慢性阻塞性肺疾病中的作用，概述了纤维细胞所起的不同作用，并讨论了它们对这些阻塞性疾病的可能贡献。
Fibrocytes are circulating cells that have fibroblast properties. They are produced by the bone marrow stroma, and they move from the blood to injured organs using multiple chemokine pathways. They exhibit marked functional and phenotypic plasticity in response to the local tissue microenvironment to ensure a proinflammatory or a more resolving phenotype. They can adopt immune cell properties and modulate conventional immune cell functions. Although their exact function is not always clear, they have emerged as key effector cells in several fibrotic diseases such as keloid, scleroderma, and idiopathic pulmonary fibrosis. Recent evidence suggests that fibrocytes could contribute to bronchial obstructive diseases such as asthma and chronic obstructive pulmonary disease. This review summarizes the reported roles of fibrocytes and their pathways into the lung in the context of asthma and chronic obstructive pulmonary disease, provides an overview of the different roles played by fibrocytes, and discusses their possible contributions to these obstructive diseases.