Wireless Bladder Pressure Monitor for Closed-Loop Bladder Neuromodulation.
Wireless Bladder Pressure Monitor for Closed-Loop Bladder Neuromodulation.
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用于闭环膀胱神经调节的无线膀胱压力监测仪。
DOI：
10.1109/icsens.2016.7808967
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Damaser,MargotS
中科院分区：
文献类型：
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作者：
Majerus,Steve;Basu,AnishaS;Makovey,Iryna;Wang,Peng;Zhui,Hui;Zorman,Christian;Ko,Wen;Damaser,MargotS
条件神经调节是一种闭环膀胱控制形式，其中对膀胱压力变化施加神经刺激。目前基于外置导管的方法在慢性门诊治疗中的应用有限。我们开发了一种无线压力监测器，提供实时、无导管的膀胱收缩检测。该装置的尺寸适合慢性植入膀胱肌肉。该压力监测器由超低功耗专用集成电路（ASIC）、微机电（MEMS）压力传感器、射频天线和可充电电池组成。在这里，我们描述了该系统的概述，包括非密封聚合物传感器封装的慢性体内测试数据和大型动物模型中无线传感器的慢性测试。实验结果表明，该封装方法对于植入式压力传感器的慢性封装是可行的。压力监测器的长期测试揭示了与膀胱壁内选择的植入部位有关的一些障碍。然而，慢性无线设备功能得到证实，数据质量足以检测大型动物的膀胱压迫，平均相关系数为0.90。
Conditional neuromodulation is a form of closed-loop bladder control where neurostimulation is applied in reaction to bladder pressure changes. Current methods based on external catheters have limited utility for chronic ambulatory therapy. We have developed a wireless pressure monitor to provide real-time, catheter-free detection of bladder contractions. The device is sized for chronic implantation in the bladder muscle. The pressure monitor consists of an ultra-low-power application specific integrated circuit (ASIC), micro-electro-mechanical (MEMS) pressure sensor, RF antennas, and rechargeable battery. Here we describe an overview of the system, including chronic in vivo test data of a non-hermetic polymer sensor package and chronic testing of the wireless sensor in large animal models. Test results show that the packaging method is viable for chronic encapsulation of implanted pressure sensors. Chronic testing of the pressure monitor revealed some obstacles relating to the chosen implant site within the bladder wall. However, chronic wireless device function was confirmed and data quality was sufficient to detect bladder compressions in large animals, with average correlation coefficient of 0.90.