Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats
Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats
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DOI：
10.1152/ajpheart.1999.277.2.h551
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发表时间：
1999-08-01
影响因子：
4.8
通讯作者：
Dewhirst, MW
中科院分区：
文献类型：
--
作者：
Braun, RD;Lanzen, JL;Dewhirst, MW
肿瘤乏氧是肿瘤放射治疗的主要障碍。通常肿瘤缺氧以两种形式发生：慢性和急性。虽然急性缺氧的存在早已被承认，但其时间特征从未被直接测量和记录。在这项研究中，肿瘤Po-2，血流量（BF），动脉血压（BP）的同时测定9 Fischer 344大鼠轴承R3230 Ac大鼠乳腺癌的左后腿皮下组织。我们测量PO-2在一个单一的位置为36-125分钟，使用凹尖氧微电极。同时，我们使用激光多普勒血流仪（LDF）测量肿瘤内两个部位的肿瘤BF。在7只非荷瘤大鼠的四头肌中进行了类似的记录。对Po-2、肿瘤BF和BP记录进行傅立叶分析。Po-2和BF显示低频波动（
Tumor hypoxia is a major barrier to tumor radiation therapy. Typically tumor hypoxia occurs in two forms: chronic and acute. Although the existence of acute hypoxia has long been acknowledged, its temporal characteristics have never been directly measured and documented. In this study tumor Po-2, blood flow (BF), and arterial blood pressure (BP) were measured simultaneously in nine Fischer 344 rats bearing R3230Ac rat mammary adenocarcinomas in the subcutis of the left hindleg. We measured Po-2 at a single location for 36-125 min using recessed-tip oxygen microelectrodes. Simultaneously, we measured tumor BF at two sites within the tumor using laser-Doppler flowmetry (LDF). Similar recordings were made in the quadriceps muscle of seven non-tumor-bearing rats. The Po-2, tumor BF, and BP records were subjected to Fourier analysis. Po-2 and BF showed low-frequency fluctuations (