Effects of clozapine on smoking in chronic schizophrenic outpatients.
Effects of clozapine on smoking in chronic schizophrenic outpatients.
复制标题
氯氮平对慢性精神分裂症门诊患者吸烟的影响。
DOI：
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发表时间：
1995
影响因子：
5.3
通讯作者：
S. Woods
中科院分区：
文献类型：
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作者：
T. George;M. Sernyak;D. Ziedonis;S. Woods
背景
在门诊慢性精神分裂症患者中观察了氯氮平对吸烟的影响。
方法
采用半结构式问卷对30例精神分裂症患者在服用氯氮平前后的吸烟情况进行回顾性调查。
结果
吸烟者占患者的62%（N = 18），在该组中，与接受典型抗精神病药物治疗的患者相比，氯氮平治疗期间报告的每日吸烟量显著减少（1.67 +/- 1.13 vs. 1.26 +/- 0.72包/天，p = 0.025）。
结论
氯氮平可能改变慢性精神分裂症患者的吸烟行为。
BACKGROUND
The effects of clozapine administration on smoking were examined in chronic schizophrenic outpatients.
METHOD
Twenty-nine of 30 schizophrenic outpatients enrolled in a university-affiliated Community Mental Health Center clozapine clinic were retrospectively surveyed by semistructured questionnaire regarding smoking before and after clozapine administration.
RESULTS
Smokers comprised 62% (N = 18) of patients, and within this group, there was a significant decrease in reported daily cigarette use during clozapine treatment compared with level of use when patients had been treated with typical neuroleptics (1.67 +/- 1.13 vs. 1.26 +/- 0.72 packs/day, p = .025).
CONCLUSION
Clozapine may alter smoking behaviors in chronic schizophrenics.