Is Flow-Mediated Dilation Nitric Oxide Mediated? A Meta-Analysis
Is Flow-Mediated Dilation Nitric Oxide Mediated? A Meta-Analysis
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DOI：
10.1161/hypertensionaha.113.02044
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发表时间：
2014-02-01
期刊：
影响因子：
8.3
通讯作者：
Thijssen, Dick H. J.
中科院分区：
文献类型：
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作者：
Green, Daniel J.;Dawson, Ellen A.;Thijssen, Dick H. J.
血流介导的血管扩张（FMD）是一种非侵入性的指标内皮功能和血管健康的人。研究一氧化氮（NO）的作用还没有定论。在这篇文章中，我们量化了NO在管道动脉FMD中的作用，并探讨了该方案（即远端袖带，约5分钟缺血）和分析方法（即自动和连续边缘检测）对该测试的NO依赖性的影响。对已发表的交叉研究进行了系统回顾和3阶段荟萃分析，这些研究测量了局部输注生理盐水或NO合酶阻断剂N（G）单甲基-L-精氨酸（L-NMMA）后的FMD。20项研究符合第1阶段的入选标准（374项个体比较）。荟萃分析的结果是输注生理盐水（即FMD生理盐水）和NO合酶阻断剂（即FMDL-NMMA）之间FMD的差异。总体而言，FMD生理盐水为8.2%（95%置信区间[CI]，6.8%-9.6%），FMDL-NMMA为3.7%（95% CI，3.1%-4.3%; P
Flow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this article, we quantified the contribution of NO in FMD of conduit arteries and explored the effect of the protocol (ie, distal cuff, approximate to 5-minute ischemia) and method of analysis (ie, automated and continuous edge detection) on the NO dependency of this test. A systematic review and 3-stage meta-analysis of published crossover studies that measured FMD under local infusion of saline or the NO synthase blocker N(G)monomethyl-L-arginine (L-NMMA) was undertaken. Twenty studies met the inclusion criteria for stage 1 (374 individual comparisons). The meta-analyzed outcome was the difference in FMD between infusion of saline (ie, FMDsaline) and NO synthase blocker (ie, FMDL-NMMA). Overall, FMDsaline was 8.2% (95% confidence interval [CI], 6.8%-9.6%) compared with FMDL-NMMA of 3.7% (95% CI, 3.1%-4.3%; P