Neurological disorders in three workers exposed to 1-bromopropane
Neurological disorders in three workers exposed to 1-bromopropane
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DOI：
10.1539/joh.44.1
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发表时间：
2002-01-01
影响因子：
3
通讯作者：
Takeuchi, Y
中科院分区：
文献类型：
--
作者：
Ichihara, G;Miller, JK;Takeuchi, Y
一名35岁的女工出现咽喉痛、蹒跚、吞咽困难、小便失禁和麻木感，腿部、大腿、臀部和下背部有烧灼感，会阴部麻木。她正在喷胶水，用聚氨酯泡沫部件组成一个垫子。在开始使用主要含有1-溴丙烷的胶水一年后，她无法自己站起来。第二个病例是一名30岁的女工，在开始从事同样的工作六个月后出现步态蹒跚、感觉异常、尿失禁、声音模糊、吞咽困难、手、腿、下背部、臀部和会阴麻木或感觉异常。第三个病例是一名50岁的女工，在开始工作两个月后出现蹒跚、脚、大腿、下背部和臀部麻木和感觉异常以及头痛的迹象。改善通风后，暴露浓度的每日时间加权平均值范围为60至261 ppm（平均值133，N=11）。三名工人的共同体征是蹒跚、麻木伴感觉异常/感觉迟钝，以及腿部振动感显著下降和中枢神经系统的各种症状。异常感觉分布在裤袜覆盖的区域，而不是手套-长袜。考虑到感觉异常/感觉迟钝和感觉缺陷的分布，不仅周围神经，而且脊髓或脑干也疑似受损。腹泻、小便失禁和出汗异常也提示自主神经系统紊乱。1-溴丙烷可能会导致人类外周神经和/或中枢神经系统的神经系统疾病。
A 35-yr-old female worker developed sore throat, stumbling, dysphagia, incontinence of urination and numbness with a burning sensation in the legs, thighs, hips and lower back as well as numbness in the perineum. She was spraying a glue to compose a cushion with polyurethane foam parts. One year after beginning to use a glue containing mainly 1-bromopropane, she became unable to stand up by herself. The second case, a 30-yr-old female worker developed a staggering gait, paresthesia, urinary incontinence, slurred voice, dysphagia, numbness or paresthesia in the hands, legs, lower back, hips and perineum, six months after beginning the same task. The third case, a 50-yr-old female worker showed signs of staggering, and numbness and paresthesias in the feet, thighs, lower back and hips, and headache, two months after starting the work. The daily time-weighted average of exposure concentrations ranged from 60 to 261 ppm (mean 133, N=11) after the ventilation was improved. The common signs in the three workers were staggering, numbness with paresthesia/dysesthesia, as well as a remarkable decrease in vibration sense in the legs and various symptoms in the central nervous system. Abnormal sensation was distributed to the area covered by pantyhose, rather than glove-stocking. Not only peripheral nerves, but also the spinal cord or brainstem was suspected to be impaired, given the paresthesia/dysesthesia and the distribution of sense deficits. Their diarrhea, incontinence of urination and abnormal sweating also suggested disorders in the autonomous nervous system. 1-Bromopropane might induce neurological disorders in the peripheral nerves and/or the central nervous system in humans.