Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease.
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease.
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DOI：
10.1146/annurev-biochem-060608-102511
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发表时间：
2011
影响因子：
16.6
通讯作者：
Lagerlof O
中科院分区：
文献类型：
--
作者：
Hart GW;Slawson C;Ramirez-Correa G;Lagerlof O
o - glcn酰化是在细胞核和细胞质蛋白的丝氨酸或苏氨酸残基上添加β- d - n -乙酰氨基葡萄糖。O-linked N-acetylglucosamine （O-GlcNAc）直到20世纪80年代初才被发现，至今仍难以检测和量化。尽管如此，O-GlcNAc是高度丰富的，并且在蛋白质上循环的时间尺度与蛋白质磷酸化相似。O-GlcNAc存在于从一些细菌到原生动物和后生动物的生物体中，包括植物和线虫，沿着进化树一直到人类。o - glcn酰化主要发生在核蛋白上，但也发生在包括线粒体在内的所有细胞内。最近的糖糖分析表明，o - glcn酰化与磷酸化有着惊人的广泛的交叉对话，在磷酸化中，它作为一种营养/应激传感器来调节信号传导、转录和细胞骨架功能。异常数量的o - glcn酰化是糖尿病胰岛素抵抗和葡萄糖毒性的基础，这种类型的修饰在神经退行性疾病中起直接作用。许多致癌蛋白和肿瘤抑制蛋白也受o - glcn酰化调节。目前的数据证明，为更好地理解这种看不见却又丰富的变化而进行的广泛努力是合理的。随着研究O-GlcNAc的工具变得更加便捷和可用，这一研究领域的指数级增长最终将发生。
O-GlcNAcylation is the addition of β-D-N-acetylglucosamine to serine or threonine residues of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not discovered until the early 1980s and still remains difficult to detect and quantify. Nonetheless, O-GlcNAc is highly abundant and cycles on proteins with a timescale similar to protein phosphorylation. O-GlcNAc occurs in organisms ranging from some bacteria to protozoans and metazoans, including plants and nematodes up the evolutionary tree to man. O-GlcNAcylation is mostly on nuclear proteins, but it occurs in all intracellular compartments, including mitochondria. Recent glycomic analyses have shown that O-GlcNAcylation has surprisingly extensive cross talk with phosphorylation, where it serves as a nutrient/stress sensor to modulate signaling, transcription, and cytoskeletal functions. Abnormal amounts of O-GlcNAcylation underlie the etiology of insulin resistance and glucose toxicity in diabetes, and this type of modification plays a direct role in neurodegenerative disease. Many oncogenic proteins and tumor suppressor proteins are also regulated by O-GlcNAcylation. Current data justify extensive efforts toward a better understanding of this invisible, yet abundant, modification. As tools for the study of O-GlcNAc become more facile and available, exponential growth in this area of research will eventually take place.
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影响因子：
56.9
作者：
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通讯作者：
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影响因子：
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DOI：
10.1111/j.1432-1033.1989.tb15008.x
发表时间：
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期刊：
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影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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