Depression and anxiety behaviour in a rat model of chronic migraine.
Depression and anxiety behaviour in a rat model of chronic migraine.
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慢性偏头痛大鼠模型的抑郁和焦虑行为
DOI：
10.1186/s10194-017-0736-z
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Yu S
中科院分区：
文献类型：
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作者：
Zhang M;Liu Y;Zhao M;Tang W;Wang X;Dong Z;Yu S
背景流行病学和临床研究已证明偏头痛和情感障碍之间存在共病。然而，目前尚不清楚慢性偏头痛是否会导致其他动物的情感障碍。方法采用经典的慢性偏头痛大鼠模型（重复硬脑膜炎症汤[IS]输注）通过体重、蔗糖偏好测试、旷场测试和高架十字迷宫测试来评估抑郁和焦虑行为。结果我们发现蔗糖偏好、运动和站立行为、内部动物距离百分比、开臂条目 与对照组相比，IS 组前额皮质的百分比以及血清素和多巴胺水平显着下降；联合服用低剂量阿米替林改善了这些缺陷。然而，IS 组和对照组之间的体重、内区时间百分比或开臂时间百分比没有差异。这些结果被用来创建新的抑郁和焦虑量表，以全面评估和评价大鼠情感障碍的程度。大多数慢性偏头痛动物表现出抑郁和焦虑样行为，但少数没有。结论大多数慢性偏头痛大鼠表现出抑郁和焦虑样行为。我们创建的新量表预计将在未来的研究中使用，以找出情感障碍合并症的潜在机制。
BackgroundEpidemiological and clinical studies have demonstrated comorbidity between migraine and affective disorders. However, it is unclear whether chronic migraine can lead to affective disorders in other animals.MethodsA classical chronic migraine rat model (repeated dura mater inflammatory soup [IS] infusion) was used to evaluate depression and anxiety behaviour via weight, sucrose preference test, open field test and elevated plus maze test.ResultsWe found that sucrose preference, locomotor and rearing behaviours, inner zoon distance percent, open-arm entries percent and serotonin and dopamine levels in the prefrontal cortex decreased significantly in the IS group compared with those in the control group; co-administration of low-dose amitriptyline ameliorated these deficits. However, no differences in weight, inner zone time percent, or open-arm time percent between the IS and control groups. These results were used to create new depression and anxiety scales to comprehensively assess and evaluate the degree of affective disorders in rats. Most of chronic migraine animals showed depression and anxiety like behaviors but a few didn’t.ConclusionsMost of the chronic migraine rats were present depression and anxiety like behaviors. The new scales we created are expected to use in the future studies to find out the potential mechanism of affective disorders’ comorbidity.