Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ
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DOI：
10.1101/gad.13.12.1561
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发表时间：
1999-06-15
影响因子：
10.5
通讯作者：
Dey, SK
中科院分区：
文献类型：
--
作者：
Lim, H;Gupta, RA;Dey, SK
我们以前已经证明，环氧合酶-2（COX-2），在生物合成的前列腺素（PGs）的限速酶，是必不可少的胚泡植入和蜕膜化。然而，参与这些进程的候选保护性群体及其作用机制仍不明确。使用COX 2缺陷小鼠和多种方法，我们在此证明COX 2衍生的前列环素（PGI（2））是植入和蜕膜化所必需的主要PG。几条证据表明，PGI（2）的作用是通过其激活核激素受体PPAR δ介导的，证明了该受体信号传导途径的首次报道的生物学功能。
We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate-limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches, we demonstrate herein that COX2-derived prostacyclin (PGI(2)) is the primary PG that is essential for implantation and decidualization. Several lines of evidence suggest that the effects of PGI(2) are mediated by its activation of the nuclear hormone receptor PPAR delta, demonstrating the first reported biologic function of this receptor signaling pathway.