An Examination of Brain Abnormalities and Mobility in Individuals with Mild Cognitive Impairment and Alzheimer's Disease.
An Examination of Brain Abnormalities and Mobility in Individuals with Mild Cognitive Impairment and Alzheimer's Disease.
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DOI：
10.3389/fnagi.2017.00086
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发表时间：
2017
影响因子：
4.8
通讯作者：
Gleason CE
中科院分区：
文献类型：
--
作者：
Fischer BL;Bacher R;Bendlin BB;Birdsill AC;Ly M;Hoscheidt SM;Chappell RJ;Mahoney JE;Gleason CE
背景：老年认知能力下降患者的活动能力变化值得关注。鉴于体弱多病的老年人易受伤害，确定造成行动不便的因素至关重要。目的：研究脑结构异常（包括灰质体积减少和白质高信号）是否与认知障碍患者的活动能力受限有关，并确定认知障碍是否会介导这种关系。方法：对34例老年轻度认知障碍（MCI）合并阿尔茨海默病患者进行神经心理学评估、活动能力评估和结构脑神经影像学检查。对预测因子进行线性回归，包括六个感兴趣区域的灰质体积（ROI）和白质高强度（WMH）负担，并将移动性测量作为结果。结果：尾状核灰质体积较小与功能性运动任务的速度较慢有关。小脑体积越大，功能活动能力越慢。白质高强度负荷与活动能力无显著相关性。结论：我们的研究结果为认知障碍个体在功能性运动任务中的皮质下灰质体积和速度之间的关联提供了证据。
Background: Mobility changes are concerning for elderly patients with cognitive decline. Given frail older individuals' vulnerability to injury, it is critical to identify contributors to limited mobility. Objective: To examine whether structural brain abnormalities, including reduced gray matter volume and white matter hyperintensities, would be associated with limited mobility among individuals with cognitive impairment, and to determine whether cognitive impairment would mediate this relationship. Methods: Thirty-four elderly individuals with mild cognitive impairment (MCI) and Alzheimer's disease underwent neuropsychological evaluation, mobility assessment, and structural brain neuroimaging. Linear regression was conducted with predictors including gray matter volume in six regions of interest (ROI) and white matter hyperintensity (WMH) burden, with mobility measures as outcomes. Results: Lower gray matter volume in caudate nucleus was associated with slower speed on a functional mobility task. Higher cerebellar volume was also associated with slower functional mobility. White matter hyperintensity burden was not significantly associated with mobility. Conclusion: Our findings provide evidence for associations between subcortical gray matter volume and speed on a functional mobility task among cognitively impaired individuals.