Aging, hypertension and physiological tremor: The contribution of the cardioballistic impulse to tremorgenesis in older adults
Aging, hypertension and physiological tremor: The contribution of the cardioballistic impulse to tremorgenesis in older adults
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DOI：
10.1016/j.jns.2013.01.016
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发表时间：
2013-03-15
影响因子：
4.4
通讯作者：
Fernhall, Bo
中科院分区：
文献类型：
--
作者：
Morrison, Steven;Sosnoff, Jacob J.;Fernhall, Bo
对于老年人来说，生理性震颤的增加是一种常见的运动特征。这种增加被认为主要反映了神经肌肉系统功能的普遍下降。然而，考虑到震颤是由许多内在来源引起的，与年龄相关的其他生理功能（如心脏系统）的变化也可能对震颤输出产生负面影响。本研究的目的是探讨年龄和心输入增加（高血压）对生理性震颤的影响。记录三组患者的心率、血压和体位/静息性震颤；1)年轻、健康的成年人，2)老年、血压正常的成年人，3)老年、高血压的成年人。结果表明，老年高血压患者的体位性震颤高于年轻健康人。相干性分析揭示了所有个体血压-震颤和心率-震颤之间的显著耦合。这种耦合的强度在老年高血压患者中最大。综上所述，这些结果表明，对于老年人来说，年龄和心脏病的综合影响对生理性震颤的影响最大，而不是任何单一因素。(c) 2013 Elsevier B.V.版权所有
For older adults, an increase in physiological tremor is a common motor feature. This increase is believed to primarily reflect a general decline in function of the neuromuscular system. However, given that tremor is derived from a number of intrinsic sources, age-related changes in other physiological functions like the cardiac system may also negatively alter tremor output. The aim of this study was to examine what impact age and increased cardiac input (hypertension) have on physiological tremor. Heart rate, blood pressure, and postural/resting tremor were recorded in three groups; 1) young, healthy adults, 2) old, normotensive adults, and 3) old, hypertensive adults. The results demonstrated that the old hypertensive adults had greater postural tremor compared to the young healthy individuals. Coherence analysis revealed significant coupling between blood pressure-tremor and between heart rate-tremor for all individuals. The strength of this coupling was greatest for the older, hypertensive individuals. Together these results show that, for older adults, the combined effects of age and cardiac disease have the greatest impact on physiological tremor rather than any single factor alone. (c) 2013 Elsevier B.V. All rights reserved.