Feasibility of gamma camera system with CdWO4 detector for quantitation of yttrium-90 bremsstrahlung imaging: Monte Carlo simulation study
Feasibility of gamma camera system with CdWO4 detector for quantitation of yttrium-90 bremsstrahlung imaging: Monte Carlo simulation study
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DOI：
10.1016/j.ijleo.2016.09.090
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发表时间：
2016-12
期刊：
影响因子：
3.1
通讯作者：
Seungwan Lee;Youngjin Lee
中科院分区：
文献类型：
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作者：
Seungwan Lee;Youngjin Lee
钇-90（Y-90）作为一种治疗性放射性核素，由于其较高的发射粒子能量和纯β发射体而引起了极大的关注。在Y-90韧致辐射成像中，NaI（Tl）和GSO探测器被广泛用于探测光子，但这些探测器由于相对较低的灵敏度而不能容易地应用于该成像。在探测器候选者中，钨酸镉（CdWO 4）由于其高密度和良好的光产额而可以获得高的探测效率。本研究的目的是评估的可行性γ相机系统与CdWO 4探测器定量Y-90韧致辐射成像使用Geant 4应用断层扫描发射（GATE）。为了评估成像系统的性能，在GATE仿真中设计了Y-90点源。这些探测器采用CdWO 4、NaI（Tl）和GSO，配备了低能通用（LEGP）、中能通用（MEGP）和高能通用（HEGP）平行孔准直器。结果表明，LEGP、MEGP和HEGP探测器的平均灵敏度分别为43.76、37.16和28.22 cps/MBq。此外，在55-285 keV能窗的全平行孔准直器系统中，CdWO 4探测器系统的灵敏度高于NaI（Tl）或GSO探测器系统。然而，三种探测器的散射分数的差异非常相似。结果表明，利用GATE模拟方法可以研究CdWO 4探测器对Y-90韧致辐射成像的影响和可行性。综上所述，本研究结果表明，CdWO 4探测器可以实现Y-90韧致辐射成像性能的改善。
Yttrium-90 (Y-90) has attracted great attention as a therapeutic radionuclide because of higher emitted particle energy and pure beta emitter. In Y-90 bremsstrahlung imaging, NaI(Tl) and GSO detectors are widely used in detecting photon but these detectors cannot be easily applied to this imaging because of relatively low sensitivity. Among detector candidates, cadmium tungstate (CdWO4) can acquire high detection efficiency due to the high density and good light yield. The purpose of this study was to evaluate the feasibility of gamma camera system with CdWO4detector for quantitation of Y-90 bremsstrahlung imaging using a Geant4 Application for Tomographic Emission (GATE). To evaluate performance of the imaging system, a Y-90 point source was designed in GATE simulation. These detectors using CdWO4, NaI(Tl), and GSO were equipped with low energy general purpose (LEGP), medium energy general purpose (MEGP), and high energy general purpose (HEGP) parallel-hole collimators. According to the results, the average sensitivities of the CdWO4detector with LEGP, MEGP, and HEGP were 43.76, 37.16, and 28.22 cps/MBq, respectively. In addition, the sensitivity was higher for CdWO4detector system than for NaI(Tl) or GSO detector systems for all parallel-hole collimator system with 55–285 keV energy window. However, differences of scatter fraction for three detectors were very similar. Our results showed that the effect and feasibility of CdWO4detector for Y-90 bremsstrahlung imaging can be investigated by a GATE simulation. In conclusion, the results of this study suggest that CdWO4detector can be achieved improved performance of Y-90 bremsstrahlung imaging.