Synapse elimination, the size principle, and Hebbian synapses.
Synapse elimination, the size principle, and Hebbian synapses.
复制标题
突触消除、大小原理和赫布突触。
DOI：
10.1002/neu.480260211
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Stollberg,J
中科院分区：
文献类型：
--
作者：
Stollberg,J
脊椎动物神经肌肉接头处的突触消除将多神经支配的肌纤维群减少到单神经支配状态。这种发展现象（如果有的话）的功能尚未得到证实。Hebbian（相关）规则连接突触前和突触后活动和神经肌肉接头的突触强度的理论分析。结果表明：（1）相关竞争导致多神经支配减少到稳定的单神经支配状态;（2）竞争在大范围的合理参数空间内产生尺寸原理;（3）在一个显著的子范围内，竞争选择性地消除拓扑不正确的突触;（4）在地形投影误差压倒系统的情况下，误差校正和尺寸原理的发展都被中断。相关性竞争可以解释关于运动神经元的刺激或沉默亚群的影响的相互矛盾的实验结果。这也可以解释一个令人困惑的例子，即在人类神经再生过程中看到的尺寸原则的崩溃。总之，这些发现提出了一个新的假设，突触消除功能的神经肌肉接头：建立的大小原则。John Wiley & Sons，Inc.
Synapse elimination at the vertebrate neuromuscular junction reduces a polyinnervated population of muscle fibers to a monoinnervated state. The function of this developmental phenomenon (if any) is unproven. A theoretical analysis of Hebbian (correlation) rules connecting presynaptic and postsynaptic activity and synaptic strength at the neuromuscular junction is presented. The following points are demonstrated: (1) Correlational competition leads to the reduction of polyinnervation to a stable monoinnervated state; (2) the competition gives rise to the size principle over a wide range of the plausible parameter space; (3) over a significant subrange, the competition selectively eliminates topographically incorrect synapses; and (4) in cases in which topographic projection errors overwhelm the system, both error correction and the development of the size principle are disrupted. Correlational competition may explain contradictory experimental results concerning the effects of stimulating or silencing subpopulations of motor neurons. It may also explain an otherwise puzzling instance of a breakdown in the size principle seen in humans undergoing neural regeneration. Taken together, these findings suggest a novel hypothesis for the function of synapse elimination at the neuromuscular junction: the establishment of the size principle. © 1995 John Wiley & Sons, Inc.