Fetal blood flow velocimetry by phase-contrast MRI using a new triggering method and comparison with Doppler ultrasound in a sheep model: a pilot study
Fetal blood flow velocimetry by phase-contrast MRI using a new triggering method and comparison with Doppler ultrasound in a sheep model: a pilot study
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DOI：
10.1007/s10334-013-0397-0
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发表时间：
2014-06-01
影响因子：
2.3
通讯作者：
Wedegaertner, Ulrike
中科院分区：
文献类型：
--
作者：
Schoennagel, Bjoern P.;Remus, Chressen C.;Wedegaertner, Ulrike
本研究首次证明了利用新研制的多普勒超声触发器在胎儿主动脉进行心电信号触发的相位对比(PC)-MRI的可行性。5只怀有单胎(胎龄121天)的怀孕绵羊被麻醉后，使用一种新的MR兼容的胎儿心脏触发多普勒超声触发器在胎儿降主动脉(1.5T)进行胎儿2D PC-MRI。通过PC-MR测量评估操作者间的可变性，并通过对一个胎儿的重复扫描来测试重复性。通过多普勒超声测速仪进行多通道间比较。所有检查均可能触发胎儿心脏。PC-MR血流速度计显示操作者间的平均变异为3+/-A5%。平均峰值血流速度为62.5+/-A4.4 cm/S，与多普勒超声测量的62.0+/-A9.2 cm/S(P(Lord‘s U test)A/1000%)有很好的一致性
We present the first study demonstrating the feasibility of antenatal blood flow velocimetry performing ECG triggered phase-contrast (PC)-MRI in the fetal aorta by using a newly developed Doppler ultrasound trigger.Five pregnant sheep carrying singleton fetuses (gestational age 121 days) were anesthetized to undergo fetal 2D PC-MRI in the fetal descending aorta (1.5 T) using a newly developed MR-compatible Doppler ultrasound trigger for fetal cardiac triggering. Inter-operator variability was assessed for PC-MR measurements and reproducibility was tested by repeated scans in one fetus. Inter-modality comparison was performed by Doppler ultrasound velocimetry.Fetal cardiac triggering was possible in all examinations. PC-MR velocimetry revealed a mean inter-operator variability of 3 +/- A 5 %. Average peak systolic flow velocities of 62.5 +/- A 4.4 cm/s were in good agreement with Doppler ultrasound measurements of 62.0 +/- A 9.2 cm/s (p (Lord's U test) a parts per thousand