Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression
Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression
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DOI：
10.1016/s0092-8674(00)81770-5
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发表时间：
1998-10-30
期刊：
影响因子：
64.5
通讯作者：
Arber, S
中科院分区：
文献类型：
--
作者：
Lin, JH;Saito, T;Arber, S
运动功能取决于感觉神经元和运动神经元及其肌肉目标之间选择性连接的形成。这种感觉-运动回路固有的特异性的分子基础尚不清楚。我们发现运动神经元池和肌肉感觉传入的亚群可以通过ETS基因的表达来定义，特别是PEA3和ER81。PEA3和ER81的表达在功能上相互连接的感觉神经元和运动神经元中是一致的。肢体消融后，运动神经元和感觉神经元无法表达ETS基因，提示其表达是由外周信号协调的。因此，ETS基因可能参与了脊髓中选择性感觉-运动回路的发育。
Motor function depends on the formation of selective connections between sensory and motor neurons and their muscle targets. The molecular basis of the specificity inherent in this sensory-motor circuit remains unclear. We show that motor neuron pools and subsets of muscle sensory afferents can be defined by the expression of ETS genes, notably PEA3 and ER81. There is a matching in PEA3 and ER81 expression by functionally interconnected sensory and motor neurons. ETS gene expression by motor and sensory neurons fails to occur after limb ablation, suggesting that their expression is coordinated by signals from the periphery. ETS genes may therefore participate in the development of selective sensory-motor circuits in the spinal cord.