Redox Chain ReactionIndole and Pyrrole Alkylation with Unactivated Secondary Alcohols
Redox Chain ReactionIndole and Pyrrole Alkylation with Unactivated Secondary Alcohols
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DOI：
10.1002/anie.201209810
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发表时间：
2013-01-01
影响因子：
16.6
通讯作者：
Wu, Jimmy
中科院分区：
文献类型：
--
作者：
Han, Xinping;Wu, Jimmy
次要角色：吲哚和吡咯衍生物与未活化的仲脂肪醇通过布朗斯台德酸催化的氧化还原链反应机理烷基化。广泛的官能团耐受性已被证明，初步研究表明，1，4-还原一个假定的吲哚碳正离子是占主导地位的机制途径。
Secondary role: Indole and pyrrole derivatives are alkylated with unactivated secondary aliphatic alcohols by a Brønsted acid-catalyzed redox chain reaction mechanism. Broad functional-group tolerance has been demonstrated and preliminary studies suggest that 1, 4-reduction of a putative indolyl carbocation is the dominant mechanistic pathway.