In Vitro Interactions of Antimicrobial Combinations with Fosfomycin against KPC-2-Producing Klebsiella pneumoniae and Protection of Resistance Development
In Vitro Interactions of Antimicrobial Combinations with Fosfomycin against KPC-2-Producing Klebsiella pneumoniae and Protection of Resistance Development
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DOI：
10.1128/aac.01086-10
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发表时间：
2011-05-01
影响因子：
4.9
通讯作者：
Giamarellou, Helen
中科院分区：
文献类型：
--
作者：
Souli, Maria;Galani, Irene;Giamarellou, Helen
采用时间-杀灭法，我们研究了磷霉素与美罗培南、粘菌素或庆大霉素对17株携带bla（KPC-2）的遗传学上不同的肺炎克雷伯菌临床分离株的相互作用。美罗培南或粘菌素对64.7%和11.8%的测试分离株观察到协同作用，而与庆大霉素组合导致无差异。与单独使用磷霉素相比，所有研究的组合均显示出更好的杀菌活性，并分别阻止了69.2%、53.8%和81.8%的敏感分离株产生磷霉素耐药性。
Using time-kill methodology, we investigated the interactions of fosfomycin with meropenem or colistin or gentamicin against 17 genetically distinct Klebsiella pneumoniae clinical isolates carrying bla(KPC-2). Synergy was observed with meropenem or colistin against 64.7 and 11.8% of tested isolates, while the combination with gentamicin resulted in indifference. All studied combinations showed improved bactericidal activity, compared to fosfomycin alone and prevented the development of fosfomycin resistance in 69.2, 53.8, and 81.8% of susceptible isolates, respectively.