Isocyanide Insertion: De Novo Synthesis of Trifluoromethylated Phenanthridine Derivatives
Isocyanide Insertion: De Novo Synthesis of Trifluoromethylated Phenanthridine Derivatives
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异氰化物插入：三氟甲基化菲啶衍生物的从头合成
DOI：
10.1021/ol4026827
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发表时间：
2013-11-01
期刊：
影响因子：
5.2
通讯作者：
Yu, Shouyun
中科院分区：
文献类型：
--
作者：
Cheng, Yuanzheng;Jiang, Heng;Yu, Shouyun
介绍了一种简单、实用、环境友好的6-（三氟甲基）菲啶衍生物的制备方法，该方法采用离子型异腈插入法，由联苯异腈衍生物和Umemoto试剂合成6-（三氟甲基）菲啶。这些反应仅由无机碱以良好至优异的化学产率促进，而不需要任何外部化学计量的氧化剂和自由基引发剂。
A mechanistically new strategy has been described for the simple, practical, and environmentally friendly preparation of 6-(trifluoromethyl)phenanthridine derivatives using ionic isocyanide insertion from biphenyl isocyanide derivatives and Umemoto's reagent. These reactions were promoted only by inorganic base in good-to-excellent chemical yields without any external stoichiometric oxidants and radical initiators.