Termitomycesphins A-D, novel neuritogenic cerebrosides from the edible Chinese mushroom Termitomyces albuminosus
Termitomycesphins A-D, novel neuritogenic cerebrosides from the edible Chinese mushroom Termitomyces albuminosus
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DOI：
10.1016/s0040-4020(00)00548-2
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发表时间：
2000-08-04
期刊：
影响因子：
2.1
通讯作者：
Sakagami, Y
中科院分区：
文献类型：
--
作者：
Qi, JH;Ojika, M;Sakagami, Y
从食用菌鸡枞菌（Termitomycesalbuminosus（Berk.）舵手（中文为“继宗”），可诱导大鼠PC 12细胞的神经元分化。通过光谱学方法和化学衍生化方法确定了其绝对立体结构。这些新的糖苷具有独特的C19羟基化鞘氨醇碱基，在中间具有分支。具有C16 α-羟基脂肪酸的白蚁菌素A和C显示出比具有C18 α-羟基脂肪酸的白蚁菌素B和D更高的神经突发生活性。(C)2000爱思唯尔科技有限公司版权所有。
Four novel cerebrosides, termitomycesphins A-D, were isolated from the edible Chinese mushroom Termitomyces albuminosus (Berk.) Helm. ('Jizong' in Chinese), shown to induce neuronal differentiation in rat PC12 cells. The absolute stereostructures were elucidated by spectroscopic methods and chemical derivatization. These new cerebrosides have a unique C19 hydroxylated sphingosine base with branching around the middle. Termitomycesphins A and C possessing a C16 alpha-hydroxy fatty acid showed a higher neuritogenic activity than did termitomycesphins B and D possessing a C18 alpha-hydroxy fatty acid. (C) 2000 Elsevier Science Ltd. All rights reserved.