PARKINSONS-DISEASE AND THE ENVIRONMENT IN EARLY-LIFE
PARKINSONS-DISEASE AND THE ENVIRONMENT IN EARLY-LIFE
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DOI：
10.1016/0022-510x(95)00148-u
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发表时间：
1995-10-01
影响因子：
4.4
通讯作者：
OSMOND, C
中科院分区：
文献类型：
--
作者：
MARTYN, CN;OSMOND, C
为了探讨胎儿时期和婴儿期遇到的环境因素与帕金森病发病风险之间的可能关系，在英国赫特福德郡东部的42个全科医生中进行了一项病例对照研究(172例，343例年龄和性别匹配的对照)。从本世纪上半叶健康访客的记录中获得了出生在赫特福德郡的受试者在出生后第一年的出生体重和生长发育信息。通过问卷调查获得兄弟姐妹的大小、出生顺序中的位置、住房类型、早期生活环境的其他特征以及儿童常见感染经历等信息。出生体重、1岁时的体重或童年家庭环境的任何方面都与患帕金森氏症的风险改变无关。与对照组相比，病例组更有可能在儿童时期患上哮喘(优势比4.1，95%可信区间1.1~16.1)或白喉(优势比2.3，95%可信区间1.2~4.7)，但没有其他感染与帕金森病的相对风险增加相关。与对照组相比，患者从未吸烟的可能性更大(优势比2.0，95%可信区间1.1至3.6)。这项研究的结果并不表明胎儿或婴儿期发育不良在帕金森氏症的病因学上很重要，但他们暗示，早期感染可能在一定程度上决定了该病的易感性。
To explore a possible relationship between environmental factors encountered during fetal life and infancy and the later risk of developing Parkinson's disease, a case-control study (172 cases, 343 age- and sex-matched controls) was carried out in 42 general practices in the eastern part of Hertfordshire, England. Information about birthweight and growth during the first year of life was obtained for subjects who had been born in Hertfordshire from records made by health visitors in the first part of the century. Information concerning size of sibship, position in the birth order, type of housing, other features of the environment in early life and experience of the common infections of childhood was obtained by questionnaire. Neither birthweight, weight at 1 year of age nor any aspect of the childhood domestic environment were associated with an altered risk of Parkinson's disease. Cases were more likely to recall suffering from croup (odds ratio 4.1, 95% CI 1.1 to 16.1) or diphtheria (odds ratio 2.3, 95% CI 1.2 to 4.7) in childhood than controls but no other infection was associated with an increased relative risk for Parkinson's disease. Cases were more likely than controls never to have smoked cigarettes (odds ratio 2.0, 95% CI 1.1 to 3.6). The results of this study do not suggest that poor growth in fetal life or infancy is important in the aetiology of Parkinson's disease but they hint that early infection might partly determine susceptibility to the disease.