Biomarkers for Primary Sjögren's Syndrome.
Biomarkers for Primary Sjögren's Syndrome.
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DOI：
10.1016/j.gpb.2015.06.002
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Zheng SG
中科院分区：
文献类型：
--
作者：
Chen W;Cao H;Lin J;Olsen N;Zheng SG
原发性干燥综合征(PSS)是一种全身性自身免疫性疾病，伴有外分泌腺功能障碍和多器官受累。最近对PSS发病机制的研究进展为寻找新的诊断和评估疾病活动性的生物标志物提供了机会。从唾液和泪液中筛选非侵入性生物标志物具有重要的潜力。在PSS中对特定和敏感的生物标记物候选者的需求是显著的。本综述旨在总结Sjögren综合征生物标记物鉴定的最新进展，试图确定可用于指导治疗决策的可靠、敏感和特异的生物标记物。
Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease with exocrine gland dysfunction and multi-organ involvement. Recent progress in understanding the pathogenesis of pSS offers an opportunity to find new biomarkers for the diagnosis and assessment of disease activity. Screening noninvasive biomarkers from the saliva and tears has significant potential. The need for specific and sensitive biomarker candidates in pSS is significant. This review aims to summarize recent advances in the identification of biomarkers of Sjögren syndrome, trying to identify reliable, sensitive, and specific biomarkers that can be used to guide treatment decisions.