Quantity of Intraretinal Hyperreflective Foci in Patients With Intermediate Age-Related Macular Degeneration Correlates With 1-Year Progression
Quantity of Intraretinal Hyperreflective Foci in Patients With Intermediate Age-Related Macular Degeneration Correlates With 1-Year Progression
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DOI：
10.1167/iovs.18-24143
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发表时间：
2018-07-01
影响因子：
4.4
通讯作者：
Sadda, Srinivas R.
中科院分区：
文献类型：
--
作者：
Nassisi, Marco;Fan, Wenying;Sadda, Srinivas R.
目的。本研究的目的是评估中度 AMD 眼中视网膜内高反射灶 (HRF) 的数量与进展为晚期 AMD 之间的相关性。对 114 名患者 114 只眼睛的体积光学相干断层扫描 (OCT) 扫描进行了回顾性审查。 HRF 进行了定性和定量评估。对来自中视网膜的五个连续正面板进行阈值化以隔离 HRF。将这五个板重新组合，并在整个 6 x 6 毫米图像 (HRFTOT) 以及中央 3 毫米 (HRF3mm) 和 5 毫米 (HRF5mm) 区域内测量 HRF 面积。这些测量结果与 1 年随访后晚期 AMD（定义为脉络膜新生血管 [CNV] 和/或完全 RPE 和光感受器萎缩 [cRORA]）的发展相关。 结果。所有三个区域的 HRF 面积均与进展至晚期 AMD 显着相关：HRF3mm 的 R = 0.610，HRF5mm 的 R = 0.622，HRFTOT 的 R = 0.614（所有 P < 0.001）。与单独进展为 cRORA 相关性仍然显着，但与单独进展为 CNV 无关。虽然 HRF 的定性评估（即 HRF 的存在：是或否）也显示与晚期 AMD 的进展（R = 0.454，P < 0.001）和单独的萎缩（R = 0.445，P < 0.001）具有显着相关性，但它们比 HRF 量化的评估弱。结论。患有中期 AMD 的眼睛通过面部 OCT 得到的 HRF 面积与进展为晚期 AMD 的 1 年风险相关，特别是与萎缩的发展相关。
PURPOSE. The purpose of this study was to evaluate the correlation between quantity of intraretinal hyperreflective foci (HRF) in the eye with intermediate AMD and progression to late AMD.METHODS. Volume optical coherence tomography (OCT) scans from 114 eyes of 114 patients were retrospectively reviewed. HRF were assessed both qualitatively and quantitatively. Five sequential en face slabs from midretina were thresholded to isolate the HRF. These five slabs were recombined, and HRF area was measured in the whole 6 x 6-mm image (HRFTOT) and within the central 3-mm (HRF3mm) and 5-mm (HRF5mm) regions. These measurements were correlated with the development of late AMD (defined as choroidal neovascularization [CNV] and/or complete RPE and photoreceptor atrophy [cRORA]) after 1 year of follow-up.RESULTS. HRF area in all three regions showed significant correlations with progression to late AMD: R = 0.610 for HRF3mm, R = 0.622 for HRF5mm, and R = 0.614 for HRFTOT (all P < 0.001). Correlations remained significant with progression to cRORA alone, though not for progression to CNV alone. While qualitative assessment of HRF (i.e., presence of HRF: yes or no) also showed a significant correlation with progression to late AMD (R = 0.454, P < 0.001) and atrophy alone (R = 0.445, P < 0.001), they were weaker than by HRF quantification.CONCLUSIONS. The area of HRF from en face OCT in eyes with intermediate AMD correlates with the 1-year risk of progression to late AMD, and in particular with the development of atrophy.