Boosting vaccine efficacy the natural (killer) way.
Boosting vaccine efficacy the natural (killer) way.
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DOI：
10.1016/j.it.2015.07.004
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发表时间：
2015-09
影响因子：
16.8
通讯作者：
Waggoner SN
中科院分区：
文献类型：
--
作者：
Rydyznski CE;Waggoner SN
在接种疫苗后，固有免疫系统和适应性免疫系统的协同对于保护性体液免疫和细胞免疫的产生至关重要。自然杀伤（NK）细胞是固有免疫系统的一线战士，近期研究揭示了NK细胞在长效免疫记忆以及适应性免疫应答调节方面的功能。这些发现表明，NK细胞可能在有效疫苗的研发以及某些情况下免疫失败中发挥重要作用。在此，我们综述了目前对NK细胞免疫调节和记忆分化能力的理解。我们研究了这些机制的环境依赖性以及NK细胞介导的免疫应答调节的本质，并讨论了这些见解如何影响免疫策略以及下一代疫苗的研发。
Coordination of the innate and adaptive immune systems is paramount to the development of protective humoral and cellular immunity following vaccination. Natural killer (NK) cells are front-line soldiers of the innate immune system, and recent studies have revealed functions for NK cells in long-lived immune memory and the regulation of adaptive immune responses. These findings suggest that NK cells may play important roles in the development of efficacious vaccines, as well as, in some contexts, failed immunizations. Here we review the current understanding of the immunomodulatory and memory differentiation capabilities of NK cells. We examine the context-dependency of the mechanisms and the nature NK cell-mediated modulation of the immune response, and discuss how these insights may impact immunization strategies and the development of next-generation vaccines.