The Association of Lower Urinary Tract Symptoms, Depression and Suicidal Ideation: Data from the 2005-2006 and 2007-2008 National Health and Nutrition Examination Survey
The Association of Lower Urinary Tract Symptoms, Depression and Suicidal Ideation: Data from the 2005-2006 and 2007-2008 National Health and Nutrition Examination Survey
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DOI：
10.1016/j.juro.2013.12.012
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发表时间：
2014-05-01
影响因子：
6.6
通讯作者：
Erickson, Bradley A.
中科院分区：
文献类型：
--
作者：
Breyer, Benjamin N.;Kenfield, Stacey A.;Erickson, Bradley A.
目的：我们研究抑郁症，自杀意念和自我报告的下尿路症状之间的关联使用一个大的，横截面，人口为基础的study.Materials和Methods：该研究包括2,890名男性从2005-2006年或2007-2008年周期的NHANES（全国健康和营养检查调查）谁是40岁或以上。询问男性是否经历过排尿困难、排尿犹豫和/或膀胱排空不全。PHQ-9（患者健康问卷-9）被用来确定临床抑郁症和自杀ideation.Results的可能性：下尿路症状的患病率分别为33.7%和10.3%的男性报告1和2个或更多的症状，分别。分别有181名（6.3%）和105名（3.6%）男性报告中度至重度抑郁（PHQ-9评分10或以上）和自杀意念。报告中度至重度抑郁症的男性（与报告轻度抑郁症的男性相比）报告下尿路症状的几率更高（PHQ-9评分5至9的校正比值比[AOR] 5.09，95% CI 3.17-8.17; PHQ-9评分10或更高的AOR 7.62，95% CI 3.90-14.87; p趋势< 0.0001）。更多的下尿路症状与中度至重度抑郁症的几率显著增加相关（1种症状的AOR 3.09，95% CI 1.86-5.15，2种或2种以上症状的AOR 8.06，95% CI 4.18-15.53，p趋势< 0.0001）和自杀意念的几率较高（AOR分别为1.70，95%CI 0.85-3.42和2.71，95%CI 1.40-5.25，p趋势-0.004）。结论：下尿路症状与抑郁/自杀意念之间存在显著相关。虽然这种关系的病理生理学及其在临床实践中的意义尚不清楚，但临床医生可能会考虑对患有严重下尿路症状的男性进行抑郁症筛查。
Purpose: We examine the association among depression, suicidal ideation and self-reported lower urinary tract symptoms using a large, cross-sectional, population based study.Materials and Methods: The study included 2,890 men from the 2005-2006 or 2007-2008 cycles of the NHANES (National Health and Nutrition Examination Survey) who were 40 years old or older. Men were asked if they experienced nocturia, urinary hesitancy and/or incomplete bladder emptying. The PHQ-9 (Patient Health Questionnaire-9) was used to determine the likelihood of clinical depression and suicidal ideation.Results: The prevalence of lower urinary tract symptoms was 33.7% and 10.3% for men reporting 1 and 2 or more symptoms, respectively. Moderate to severe depression (PHQ-9 score 10 or greater) and suicidal ideation were reported by 181 (6.3%) and 105 (3.6%) men, respectively. Men reporting moderate to severe depression (compared to those reporting minimal depression) had a higher odds of reporting lower urinary tract symptoms (adjusted odds ratio [AOR] 5.09, 95% CI 3.17-8.17 for PHQ-9 score 5 to 9 and AOR 7.62, 95% CI 3.90-14.87 for PHQ-9 score 10 or greater; p trend < 0.0001). More lower urinary tract symptoms were associated with a significantly higher odds of moderate to severe depression (AOR 3.09, 95% CI 1.86-5.15 for 1 symptom and AOR 8.06, 95% CI 4.18-15.53 for 2 or more symptoms, p trend < 0.0001) and a higher odds of suicidal ideation (AOR 1.70, 95% CI 0.85-3.42 and AOR 2.71, 95% CI 1.40-5.25, respectively, p trend - 0.004).Conclusions: A significant relationship was observed between lower urinary tract symptoms and depression/suicidal ideation. While the pathophysiology of the relationship and its significance in clinical practice remain unclear, clinicians may consider screening men with severe lower urinary tract symptoms for depression.