Assessment of glycosaminoglycan content in intervertebral discs using chemical exchange saturation transfer at 3.0 Tesla: preliminary results in patients with low-back pain
Assessment of glycosaminoglycan content in intervertebral discs using chemical exchange saturation transfer at 3.0 Tesla: preliminary results in patients with low-back pain
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DOI：
10.1007/s00330-012-2660-6
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发表时间：
2013-03-01
影响因子：
5.9
通讯作者：
Trattnig, Siegfried
中科院分区：
文献类型：
--
作者：
Haneder, Stefan;Apprich, Sebastian R.;Trattnig, Siegfried
为评价3-T磁共振成像(MRI)糖胺葡聚糖依赖的化学交换饱和转移(GagCEST)成像对腰痛(LBP)患者腰间盘(IVD)中糖胺多糖(GAG)含量的影响。MRI方案包括标准形态成像、矢状位T2标测和gagCEST成像。对纤维环(AF)和髓核(NP)进行感兴趣区分析，并对纤维环(AF)和髓核(NP)进行感兴趣区分析，然后对不同退行性IVD(Pfirmann 3+4)的GagCEST值与T2松弛时间之间的相关性进行统计学检验。退变性IVD(Pfirmann 3+4)NP的GagCEST值显著低于非退行性IVD(Pfirmann 1+2)，但仅与T2弛豫时间呈弱线性相关(r=0.299)。NP的GagCEST值与Pfirmann分级呈中度负相关(r=-0.449)。随着形态退变程度的增加，NP中已知的GAG丢失可以通过3.0T的GagCEST成像进行评估。仅与单个Pfirmann分级和T2松弛时间的相关性似乎是中等的，表明该技术提供的信息存在显著差异。欧洲中心3-T MRI提供了关于退变腰椎间盘的新的功能数据。欧洲中心GagCEST成像可以评估糖胺聚糖丢失。欧洲中心GagCEST成像和T2映射提供了关于椎间盘退变的本质不同的信息。
To evaluate glycosaminoglycan-dependent chemical exchange saturation transfer (gagCEST) imaging at 3-T magnetic resonance imaging (MRI) for quantification of glycosaminoglycan (GAG) content in intervertebral discs (IVDs) in patients with low-back pain (LBP).Sixteen patients with LBP were examined in this Institutional Review Board-approved study using a clinical whole-body system. The MRI protocol included standard morphological imaging, sagittal T2-mapping and gagCEST imaging. IVD grading according to the Pfirrmann score and region-of-interest analysis of the annulus fibrosus (AF) and the nucleus pulposus (NP) in gagCEST and T2 maps were performed before data were statistically tested for correlations between imaging techniques and quantitative differences between different grades of IVD degeneration.GagCEST values of the NP were significantly (P < 0.001) lower in degenerative IVDs (Pfirrmann 3 + 4) compared with non-degenerative IVDs (Pfirrmann 1 + 2), but only a weak linear correlation (r = 0.299) with the T2 relaxation times was found. GagCEST values of the NP exhibited a moderate negative correlation with Pfirrmann grades (r = -0.449).The known loss of GAG in the NP with increasing grade of morphological degeneration can be assessed using gagCEST imaging at 3.0 T. The correlation with single Pfirrmann grades and T2 relaxation times only seems to be moderate, indicating a substantial difference in information provided by the techniques.aEuro cent 3-T MRI offers new functional data about the degenerating lumbar discaEuro cent GagCEST imaging can assess glycosaminoglycan lossaEuro cent GagCEST imaging and T2 mapping provide substantially different information about disc degenerationaEuro cent Correlation between glycosaminoglycan loss and grade of morphological degeneration is only moderate.