Smoking is independently associated with high plasma insulin levels in nondiabetic men
Smoking is independently associated with high plasma insulin levels in nondiabetic men
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DOI：
10.2337/diacare.19.11.1229
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发表时间：
1996-11-01
期刊：
影响因子：
16.2
通讯作者：
Laakso, M
中科院分区：
文献类型：
--
作者：
Ronnemaa, T;Ronnemaa, EM;Laakso, M
目的：在相对较少的受试者中使用正常血糖钳夹技术或胰岛素抑制试验的研究表明，吸烟可能导致胰岛素抵抗。我们的目的是在一个庞大的非糖尿病男性人群中研究吸烟状况和空腹血浆胰岛素之间的关系。研究设计和方法--从人群登记中选取了616名年龄在45-之间的非糖尿病男性。结果吸烟者和既往吸烟者经年龄和体重指数调整后的胰岛素水平显著高于非吸烟者(分别为92.4、86.4和78.6pmol/L；P=0.009)。在所有体重指数中，吸烟者和戒烟者的血浆胰岛素水平高于不吸烟者。在调整了可能影响胰岛素敏感性的因素(高血压、收缩或舒张压、β-受体阻滞剂和/或利尿剂的使用、血管扩张抗高血压药物的使用、体育锻炼、酒精使用、非胰岛素依赖型糖尿病、冠心病和既往心肌梗死)后，吸烟者的胰岛素浓度仍然最高(91.2pmol/L)，戒烟者的胰岛素浓度居中(86.8pmol/L)，非吸烟者的胰岛素浓度最低(78.9pmol/L，组间P=0.008)。结论我们的结果表明，长期吸烟与高年龄和体重指数调整后的血浆胰岛素水平有关，独立于其他已知的影响胰岛素敏感性的因素。戒烟后吸烟的影响可能是部分可逆的。
OBJECTIVE - Studies using the euglycemic clamp technique or the insulin suppression test in relatively small numbers of subjects have suggested that smoking may cause insulin resistance. Our aim was to study the association between smoking status and fasting plasma insulin in a large nondiabetic male population.RESEARCH DESIGN AND METHODS - A total of 616 nondiabetic men aged 45-64 years were taken from a population register. Fasting plasma insulin and blood pressure were measured, and smoking history and medication were evaluated by interview.RESULTS - Age- and BMI-adjusted insulin levels were significantly higher in smokers and ex-smokers than in nonsmokers (92.4, 86.4, and 78.6 pmol/l, respectively; P = 0.009). In every BMI-tertile, smokers and ex-smokers had higher plasma insulin than nonsmokers. After adjustment for factors potentially affecting insulin sensitivity (hypertension, systolic or diastolic blood pressure, use of beta-blockers and/or diuretics, use of vasodilating antihypertensive drugs, physical exercise, alcohol use, parental history of NIDDM, coronary heart disease, and previous myocardial infarction), insulin concentrations were still highest in smokers (91.2 pmol/l), intermediate in ex-smokers (86.8 pmol/l), and lowest in nonsmokers (78.9 pmol/l, P = 0.008 between groups).CONCLUSIONS - Our results show that chronic smoking is associated with high age- and BMI-adjusted plasma insulin levels, independent of other factors known to influence insulin sensitivity. The effect of smoking may be partially reversible after quitting.