Facile and eco-friendly fabrication of polysaccharides-based nanocomposite hydrogel for photothermal treatment of wound infection
Facile and eco-friendly fabrication of polysaccharides-based nanocomposite hydrogel for photothermal treatment of wound infection
复制标题
简便环保地制备多糖基纳米复合水凝胶用于光热治疗伤口感染
DOI：
10.1016/j.carbpol.2019.115565
复制
发表时间：
2020-02-15
影响因子：
11.2
通讯作者：
Xu, Chen
中科院分区：
文献类型：
--
作者：
Deng, Hongling;Yu, Zhongpeng;Xu, Chen
由于有效避免了传统抗生素的缺点，光热杀灭病原菌和治疗伤口感染引起了人们的极大关注。本工作采用一种简便、环保的方法制备了含单宁酸-铁(III)(TA-Fe)纳米粒子的琼脂糖(AG)水凝胶。优化后的纳米复合水凝胶具有良好的力学性能和良好的加工性能。更重要的是，纳米复合水凝胶表现出突出的光热效应，在近红外照射10分钟时，温度急剧上升58摄氏度。体外抑菌实验表明，该水凝胶在近红外照射10min时，可有效杀灭近99%的细菌。此外，在体内实验中，纳米复合水凝胶可以有效地治疗伤口感染，促进伤口愈合。此外，该水凝胶具有较高的生物相容性。纳米复合水凝胶具有良好的力学性能、优异的光热效应和较高的生物相容性，有望成为生物医用抗菌创面敷料。
Nowadays, photothermal killing of pathogenic bacteria and treatment of wound infection have attracted great attention owing to effectively avoiding the drawbacks of traditional antibiotics. In this work, an agarose (AG)-based hydrogel containing tannic acid-Fe(III) (TA-Fe) nanoparticles was fabricated by a facile and eco-friendly strategy. The optimal nanocomposite hydrogel showed the good mechanical property and superior processability. More importantly, the nanocomposite hydrogel revealed outstanding photothermal effect, which exhibited a sharp temperature increase of 58 degrees C during NIR exposure for 10 min. With in vitro antibacterial experiment, the hydrogel could effectively kill of nearly 99 % of bacteria with 10 min of NIR irradiation. Additionally, for the in vivo experiment, the nanocomposite hydrogel could effectively cure wound infection and promote wound healing. Moreover, the hydrogel possessed high biocompatibility. Based on the good mechanical property, outstanding photothermal effect and high biocompatibility, the nanocomposite hydrogel could become a promising antibacterial wound dressings for biomedical applications.