Working memory deficits in HIV-seropositive drug users
Working memory deficits in HIV-seropositive drug users
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DOI：
10.1017/s1355617797004517
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发表时间：
1997-09-01
影响因子：
2.6
通讯作者：
Harrow, Martin
中科院分区：
文献类型：
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作者：
Bartok, John A.;Martin, Eileen M.;Harrow, Martin
我们研究了38名艾滋病毒血清阳性和20名血清阴性吸毒者的工作记忆操作的完整性，使用修改后的伦敦塔任务。这个新的任务，伦敦塔工作记忆版本（TOL-WM），包括一个延迟响应组件，除了成功执行标准TOL所需的规划。症状性HIV血清阳性参与者解决TOL-WM问题的数量明显少于匹配的血清阴性对照组。然而，血清反应阳性和血清反应阴性的受试者表现出相似的总体水平的规划效率，这表明TOL-WM赤字可能主要与未能编码或维持足够的在线记忆表示。这项研究的结果证实了我们以前的报告，可能的工作记忆缺陷的HIV-1感染，并建议工作记忆的措施，在评估艾滋病毒相关的认知缺陷有特别的效用。(JINS，1997，3，451-456.）
We studied the integrity of working memory operations in 38 HIV-seropositive and 20 seronegative drug users, using a modified version of the Tower of London task. This new task, the Tower of London-Working Memory version (TOL-WM), includes a delayed-response component in addition to the planning required for successful performance of the standard TOL. Symptomatic HIV-seropositive participants solved significantly fewer TOL-WM problems compared to matched seronegative controls. However, seropositive and seronegative subjects showed similar overall levels of planning efficiency, suggesting that the TOL-WM deficit may be associated primarily with failure to encode or maintain an adequate online memory representation. The results of this study confirm our previous report of a possible working memory deficit in HIV-1 infection and suggest that measures of working memory have particular utility in the evaluation of HIV-related cognitive deficits. (JINS, 1997, 3, 451-456.)