Helminthic therapy: improving mucosal barrier function.
Helminthic therapy: improving mucosal barrier function.
复制标题
驱虫疗法：改善粘膜屏障功能。
DOI：
10.1016/j.pt.2012.02.008
复制
发表时间：
2012
影响因子：
9.6
通讯作者：
Loke,P'ng
中科院分区：
文献类型：
--
作者：
Wolff,MartinJ;Broadhurst,MaraJ;Loke,P'ng
自身免疫性疾病和蠕虫感染的流行病学提出，蠕虫可以改善炎症状况，然后使用动物模型进行测试。这已经转化为临床研究，旨在安全和受控地重新引入蠕虫暴露于患有自身免疫性疾病的患者（所谓的“蠕虫治疗”），以减轻炎症反应。在这篇综述中，我们总结了最近的蠕虫治疗的临床试验的结果，特别注意的作用机制。而以前的评论强调蠕虫激活的免疫调节机制，我们建议，粘膜屏障功能的增强可能有同样重要的作用，在改善炎症性肠病的条件。
The epidemiology of autoimmune diseases and helminth infections led to suggestions that helminths could improve inflammatory conditions, which was then tested using animal models. This has translated to clinical investigations aimed at the safe and controlled reintroduction of helminthic exposure to patients suffering from autoimmune diseases (so-called ‘helminthic therapy') in an effort to mitigate the inflammatory response. In this review, we summarize the results of recent clinical trials of helminthic therapy, with particular attention to mechanisms of action. Whereas previous reviews have emphasized immune regulatory mechanisms activated by helminths, we propose that enhancement of mucosal barrier function may have an equally important role in improving conditions of inflammatory bowel diseases.