Alveolar T-cell subsets in pulmonary sarcoidosis. Correlation with disease activity and effect of steroid treatment.
Alveolar T-cell subsets in pulmonary sarcoidosis. Correlation with disease activity and effect of steroid treatment.
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肺结节病中的肺泡 T 细胞亚群。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
E. Stevens
中科院分区：
文献类型：
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作者：
J. Ceuppens;L. Lacquet;G. Mariën;M. Demedts;A. Eeckhout;E. Stevens
通过 35 名结节病患者的支气管肺泡灌洗获得的肺泡淋巴细胞，用针对淋巴细胞亚群的单克隆抗体进行了分析。与正常对照受试者相比，未经治疗的患者肺泡淋巴细胞群中 Leu 3a (+) T 辅助诱导细胞 (THI) 的百分比显着较高，而 Leu 2a (+) T 细胞毒性抑制细胞 (TCS) 的百分比显着较低（p 小于 0.002）。肺泡 THI 与 TCS 细胞的平均比率为 6.20 +/- 3.76，而对照组为 1.44 +/- 0.54（p 小于 0.002）。未经治疗的患者肺泡淋巴细胞中 THI 细胞相对于血液的富集百分比（p 小于 0.0002），而肺泡灌洗液中 TCS 细胞的淋巴细胞百分比低于血液中的百分比（p 小于 0.002）。在对照受试者中没有观察到这些变化。高强度肺泡炎患者（即 T 细胞占肺泡炎症细胞的 28% 或以上）的肺泡淋巴细胞中 THI 细胞的比例显着高于低强度肺泡炎患者（p 小于 0.01）。肺泡 THI 细胞的百分比与肺泡细胞百分比中淋巴细胞和 T 细胞的数量呈正相关（p 小于 0.03），两者都是疾病活动性的指标。在接受至少两次灌洗的未经治疗的患者中，发现 THI/TCS 比率下降伴随或先于放射学和临床改善，但最初的 THI/TCS 比率并不能预测进一步的演变。类固醇治疗降低了 THI/TCS 比率，同时 TCS 细胞比例显着增加。这些变化与肺泡淋巴细胞数量的影响无关。（摘要截断为 250 字）
Alveolar lymphocytes, obtained by bronchoalveolar lavage in 35 patients with sarcoidosis, were analyzed with monoclonal antibodies to lymphocyte subsets. Untreated patients had significantly higher percentages of Leu 3a (+) T helper-inducer cells (THI) and significantly lower Leu 2a (+) T cytotoxic-suppressor cells (TCS) within the alveolar lymphocyte population than did normal control subjects (p less than 0.002). The mean ratio of alveolar THI to TCS cells was 6.20 +/- 3.76 versus 1.44 +/- 0.54 in control subjects (p less than 0.002). Untreated patients had a percentual enrichment of THI cells among alveolar lymphocytes relative to blood (p less than 0.0002), whereas TCS cells in percent of lymphocytes were lower in alveolar lavage fluid than in blood (p less than 0.002). These shifts were not observed in the control subjects. Patients with high-intensity alveolitis (i.e., T cells constituted 28% or more of alveolar inflammatory cells) had significantly greater proportions of THI cells among alveolar lymphocytes than did those with low-intensity alveolitis (p less than 0.01). This percent of alveolar THI cells correlated positively with the number of lymphocytes and T cells in percent of alveolar cells (p less than 0.03), which both are indexes of disease activity. In untreated patients who were lavaged at least twice, a decrease in the THI/TCS ratio was found to accompany or precede radiologic and clinical improvement, but the initial THI/TCS ratio was not predictive of further evolution. Steroid treatment decreased the THI/TCS ratio with a marked increase in the proportion of TCS cells. These changes were independent of an effect on the number of alveolar lymphocytes.(ABSTRACT TRUNCATED AT 250 WORDS)