Crystallocryoglobulinemia resulting from human monoclonal antibodies to albumin.
Crystallocryoglobulinemia resulting from human monoclonal antibodies to albumin.
复制标题
由人白蛋白单克隆抗体引起的结晶冷球蛋白血症。
DOI：
--
复制
发表时间：
1983
影响因子：
39.2
通讯作者：
G. Bernier
中科院分区：
文献类型：
--
作者：
L. Mills;L. Brettman;J. Jentoft;E. Viner;G. Bernier
两名患者有一个以前未认识到的形式的晶体cytocryulinemia。他们的临床表现相似，包括坏死性血管炎和紫癜涉及的腿。对每个cryopulin复合物的分析表明，存在两种组分，白蛋白和单克隆IgG-λ，并且这两种组分都需要以固定的比例沉淀。此外，由于柠檬酸盐抑制复合物形成，血清中发生冷沉淀，而血浆中未发生。我们的研究结果表明，单克隆IgG抗体的性质，专门针对钙依赖性抗原位点的人白蛋白，并得到的IgG-λ-白蛋白免疫复合物在寒冷中结晶。
Two patients had a previously unrecognized form of crystallocryoglobulinemia. Their clinical presentations were similar, consisting of necrotizing vasculitis and purpura involving the legs. Analysis of each cryoglobulin complex showed that two components, albumin and a monoclonal IgG-lambda, were present, and both components were needed in a fixed ratio for precipitation. In addition, cryoprecipitation occurred in serum, but not plasma, due to citrate inhibition of complex formation. Our findings suggest that the monoclonal IgGs have the properties of antibodies directed specifically against a calcium-dependent antigenic site on human albumin, and that the resultant IgG-lambda-albumin immune complexes crystallized in the cold.