LKB1 regulated pathways in lung cancer invasion and metastasis.
LKB1 regulated pathways in lung cancer invasion and metastasis.
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DOI：
10.1097/jto.0b013e3181fbc28a
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Zhou W
中科院分区：
文献类型：
--
作者：
Marcus AI;Zhou W
转移的特征在于癌细胞侵入邻近组织、渗入血管或淋巴管以及外渗到远处组织环境中的能力。转移性疾病是NSCLC 5年生存率低的主要原因，因此明确需要了解调控NSCLC转移的分子机制。丝氨酸/苏氨酸激酶和肿瘤抑制因子LKB 1在30%的NSCLC肿瘤中发生突变，最近的证据表明其在NSCLC转移中起重要作用。本文综述了LKB 1依赖的侵袭途径，其中LKB 1功能受损可促进NSCLC转移。
Metastasis is characterized by the ability of cancer cells to invade into adjacent tissue, intravasate into blood or lymphatic vessels, and extravasate into a distant tissue environment. Metastatic disease is primarily responsible for the low 5-year survival rate of NSCLC and therefore an understanding of the molecular mechanisms that regulate NSCLC metastasis is clearly warranted. The serine/threonine kinase and tumor suppressor LKB1 is mutated in 30% of NSCLC tumors, and recent evidence points to a prominent role in NSCLC metastasis. This review summarizes LKB1-dependent invasion pathways where compromised LKB1 function could promote NSCLC metastasis.