In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents
In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents
复制标题
DOI：
10.1016/j.jacbts.2018.02.003
复制
发表时间：
2018-06-01
影响因子：
9.7
通讯作者：
Sinusas, Albert J.
中科院分区：
文献类型：
--
作者：
Boutagy, Nabil E.;Wu, Jing;Sinusas, Albert J.
活性氧（ROS）参与阿霉素诱导的心脏毒性。作者研究了ROS标记物F-18-DHMT在早期检测多柔比星诱导的大鼠心脏毒性中的有效性。超声心动图进行了基线和4，6，8周后阿霉素开始，而在体内超氧化物的生产进行了测量，在4和6周的F-18-DHMT正电子发射断层扫描。左心室射血分数（LVEF）并没有显着下降，直到6周后阿霉素治疗，而心肌超氧化物产生显着升高，在4周。F-18-DHMT成像检测到啮齿动物LVEF下降前心脏超氧化物产生的升高，并可能允许癌症患者早期心脏毒性检测。(C)2018作者由爱思唯尔代表美国心脏病学会基金会出版。
Reactive oxygen species (ROS) are involved in doxorubicin-induced cardiotoxicity. The authors investigated the efficacy of F-18-DHMT, a marker of ROS, for early detection of doxorubicin-induced cardiotoxicity in rats. Echocardiography was performed at baseline and 4, 6, and 8 weeks post-doxorubicin initiation, whereas in vivo superoxide production was measured at 4 and 6 weeks with F-18-DHMT positron emission tomography. Left ventricular ejection fraction (LVEF) was not significantly decreased until 6 weeks post-doxorubicin treatment, whereas myocardial superoxide production was significantly elevated at 4 weeks. F-18-DHMT imaging detected an elevation in cardiac superoxide production before a fall in LVEF in rodents and may allow for early cardiotoxicity detection in cancer patients. (C) 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.