Anti-aging interventions affect lifespan variability in sex, strain, diet and drug dependent fashion
Anti-aging interventions affect lifespan variability in sex, strain, diet and drug dependent fashion
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DOI：
10.18632/aging.102037
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发表时间：
2019-06-30
期刊：
影响因子：
5.2
通讯作者：
Musters, C. J. M.
中科院分区：
文献类型：
--
作者：
Bartke, Andrzej;Evans, Tracy R.;Musters, C. J. M.
最近有报告指出，与人类预期寿命差异有关的社会经济因素与死亡年龄差异有关。为了确定抗衰老干预是否也改变了寿命的变化，我们分析了接受影响衰老或限制卡路里的药物治疗的小鼠和长寿突变小鼠的数据。寿命的变化和寿命差异的关系被发现取决于性别和治疗，显然也取决于品系。用有效的抗衰老药物治疗的雄性小鼠的寿命增加的同时，死亡年龄的变化也减少了，早期的死亡率也明显降低。生长激素相关突变和卡路里限制导致的寿命延长只会增加女性的寿命差异。我们的结论是，抗衰老干预对实验小鼠死亡年龄的变化和个体寿命分布的影响是治疗依赖的和性二态的。
It was recently reported that socio-economic factors related differences in human life expectancy are associated with differences in the variance of age at death. To determine whether anti-aging interventions also alter the variance of longevity, we have analyzed data from mice subjected to treatment with drugs that affect aging or to calorie restriction and from long-lived mutant mice. The relationship of changes in longevity and in longevity variance was found to depend on sex and treatment and apparently also on strain. Increased longevity of male mice treated with effective anti-aging drugs was accompanied by reduced variance of age at death and apparent reduction of early life mortality. Life extension induced by growth-hormone related mutations and calorie restriction tended to increase longevity variance in females only. We conclude that impact of anti-aging interventions on the variance of age at death and distribution of individual lifespans in laboratory mice is treatment-dependent and sexually dimorphic.