Prostaglandin E2 Effect from the Luminal Side on Renal Tubular 22Na Efflux: Tracer Microinjection Studies 1
Prostaglandin E2 Effect from the Luminal Side on Renal Tubular 22Na Efflux: Tracer Microinjection Studies 1
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管腔侧前列腺素 E2 对肾小管 22Na 流出的影响：示踪剂显微注射研究 1
DOI：
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发表时间：
1977
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通讯作者：
M. Kauker
中科院分区：
文献类型：
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作者：
M. Kauker
摘要采用肾微创技术，观察腔内前列腺素E_2(PGE_2)对高渗盐水利尿大鼠同时给予22Na后净流出的影响。[~3H]菊粉和~(22)NaC l分别注入和不加前列腺素E_2后近曲小管腔内注射，观察尿液中~3H和~(22)Na的恢复情况。在有PGE2存在的情况下，钠回收率显着较高，而肾功能、注射方法和部位相似。我要感谢E.E.Elko博士和F.D.Sticht博士对这份手稿的批判性阅读。
Summary Using renal micropuncture techniques, the effect of luminal PGE2 on the net efflux of simultaneously administered 22Na was examined in rats in hyper-tonic saline diuresis. [3H]Inulin and 22NaCl were microinjected into the lumen of late-proximal convoluted tubules with and without PGE2, and the urinary recovery of 3H and 22Na were followed. Sodium recovery was significantly higher in the presence of PGE2 while renal function and the method and site of injection were similar. I wish to thank Dr. E. E. Elko and Dr. F. D. Sticht for the critical reading of this manuscript.