Hypermutability and silent mutations in human carcinogenesis.
Hypermutability and silent mutations in human carcinogenesis.
复制标题
人类致癌过程中的超突变和沉默突变。
DOI：
10.1006/scbi.1998.0092
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Strauss,BS
中科院分区：
文献类型：
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作者：
Strauss,BS
沉默或同义突变是不导致氨基酸变化的核苷酸变化。在包含近 10,000 个突变的数据库中，此类改变约占 TP53 突变总数的 4%。只要这些变化不赋予选择性优势，沉默突变就可以估计无偏突变频率。由于该频率至少比正常组织的预期高 100 倍，因此肿瘤必定是高度可变的。此外，一类肿瘤可能是超突变的，其突变频率与免疫多样性产生中观察到的突变频率相当。
Silent or synonymous mutations are nucleotide changes which do not result in an amino acid change. Such alterations make up approximately 4% of the total TP53 mutations in a database of almost 10,000 mutations. Insofar as these changes do not confer a selective advantage, silent mutations make it possible to estimate an unbiased mutation frequency. Since this frequency is at least 100 times higher than would be expected for normal tissue, tumors must be hypermutable. In addition, a class of tumors may be supermutable with a mutation frequency comparable to that observed in the generation of immune diversity.