Distinct functional roles of cytoplasmic dynein defined by the intermediate chain isoforms.
Distinct functional roles of cytoplasmic dynein defined by the intermediate chain isoforms.
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DOI：
10.1016/j.yexcr.2014.12.013
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发表时间：
2015-05-15
影响因子：
3.7
通讯作者：
Pfister, K. Kevin
中科院分区：
文献类型：
--
作者：
Pfister, K. Kevin
The motor protein, cytoplasmic dynein is responsible for the movement of a variety of cargoes toward microtubule minus ends in cells. Little is understood about how dynein is regulated to specifically transport its various cargoes. In vertebrates, the dynein motor domain (DYNC1H) is encoded by a single gene; while there are two genes for the five smaller subunits that comprise the cargo binding domain of the dynein complex. The isoforms of the intermediate chain (DYNC1I) provide a good model system with which to study the roles the different isoforms of the cargo domain subunits have in designating specific dynein functions. The intermediate chains (DYNC1I) play a key scaffold role in the dynein complex. In neurons, dynein complexes with different intermediate chain isoforms have distinct roles, including cargo binding and transport. Some of the phospho-isoforms of the intermediate chain also specify binding to specific cargo. These data support the model that cytoplasmic dynein can be specifically regulated through the different isoforms of the subunits.
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影响因子：
4.8
作者：
Lo, KWH;Kan, HM;Pfister, KK
通讯作者：
Pfister, KK
DOI：
10.1523/jneurosci.5599-11.2012
发表时间：
2012-10-31
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Mitchell DJ;Blasier KR;Jeffery ED;Ross MW;Pullikuth AK;Suo D;Park J;Smiley WR;Lo KW;Shabanowitz J;Deppmann CD;Trinidad JC;Hunt DF;Catling AD;Pfister KK
通讯作者：
Pfister KK
DOI：
10.1083/jcb.141.2.443
发表时间：
1998-04-20
期刊：
The Journal of cell biology
影响因子：
--
作者：
Gindhart JG Jr;Desai CJ;Beushausen S;Zinn K;Goldstein LS
通讯作者：
Goldstein LS
影响因子：
3.3
作者：
King, SJ;Brown, CL;Schroer, TA
通讯作者：
Schroer, TA
影响因子：
4.8
作者：
Mok, YK;Lo, KWH;Zhang, MJ
通讯作者：
Zhang, MJ