Time course of osteoporotic vertebral fractures by magnetic resonance imaging using a simple classification: a multicenter prospective cohort study
Time course of osteoporotic vertebral fractures by magnetic resonance imaging using a simple classification: a multicenter prospective cohort study
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DOI：
10.1007/s00198-016-3737-x
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发表时间：
2017-02-01
影响因子：
4
通讯作者：
Nakamura, H.
中科院分区：
文献类型：
--
作者：
Takahashi, S.;Hoshino, M.;Nakamura, H.
本研究通过磁共振成像使用简单的分类揭示了退行性椎体骨折的时间进程。信号改变与骨折椎体的受压程度和活动度有关。这种分类显示了足够的可靠性，在分类的磁共振成像表现的骨质疏松性椎体骨折。磁共振成像（MRI）是有用的诊断骨质疏松性椎体骨折（OVFs）。本研究采用简单分类法，通过MRI研究OVFs的时间进程。这项多中心队列研究于2012年至2015年进行。在11个机构中招募了患有ae 2周龄OVF的连续性患者。在入组时以及1、3、6和12个月随访时进行MRI。根据信号强度对T1 WI、T2 WI和短τ反转恢复（STIR）信号改变进行分类。对153例患者进行了6个月的随访。入组时，骨折椎体信号改变在T1 WI上为43%弥漫性和57%局限于低信号;在T2 WI上，分别为56%、24%和5%局限于低信号、高信号和弥漫性低信号;在STIR上，100%为高信号。在T1 WI上，弥漫性低仍然是最常见的（1个月时为90%，3个月时为60%），直到6个月和12个月时，大多数都是局限性低（分别为54%和52%）。在T2 WI上，局限性低位仍然最常见（12个月时降至41%）。在STIR上，在3、6和12个月时分别有98%、87%和64%显示高信号变化。术后3、6、12个月，弥漫性低信号改变与椎体高度显著降低相关，高信号改变与椎体角运动显著增大相关，MRI信号改变与骨折椎体压缩程度和角运动相关。该分类显示了对OVF MRI结果进行分类的足够可靠性。
This study revealed the time course of osteoporotic vertebral fracture by magnetic resonance imaging using a simple classification. Signal changes were associated with the compression degree and mobility of the fractured vertebral body. This classification showed sufficient reliability in categorizing magnetic resonance imaging findings of osteoporotic vertebral fractures.Magnetic resonance imaging (MRI) is useful in diagnosing osteoporotic vertebral fractures (OVFs). This study investigated the time course of OVFs by MRI using a simple classification.This multicenter cohort study was performed from 2012 to 2015. Consecutive patients with ae2-week-old OVFs were enrolled in 11 institutions. MRI was performed at enrollment and at 1-, 3-, 6-, and 12-month follow-up. Signal changes on T1-weighted imaging (T1WI), T2WI, and short tau inversion recovery (STIR) were classified according to signal intensity. Height and angular motion of vertebral bodies were also measured.The 6-month follow-up was completed by 153 patients. At enrollment, fractured vertebrae signal changes were 43 % diffuse and 57 % confined low on T1WI; on T2WI, 56, 24, and 5 % were confined low, high, and diffuse low, respectively; on STIR, 100 % were high. On T1WI, diffuse low remained most common (90 % at 1 month and 60 % at 3 months) until 6 and 12 months, when most were confined low (54 and 52 %, respectively). On T2WI, confined low remained most common (decreasing to 41 % at 12 months). On STIR, high signal change was shown in 98, 87, and 64 % at 3, 6, and 12 months, respectively. At 3, 6, and 12 months, diffuse low signal change was associated with significantly lower vertebral height, and high signal change was associated with significantly greater angular motion.MRI signal changes were associated with the compression degree and angular motion of fractured vertebrae. This classification showed sufficient reliability in categorizing MRI findings of OVFs.