News from the PUB: plant U-box type E3 ubiquitin ligases.
News from the PUB: plant U-box type E3 ubiquitin ligases.
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DOI：
10.1093/jxb/erx411
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发表时间：
2018-01
影响因子：
6.9
通讯作者：
M. Trujillo
中科院分区：
文献类型：
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作者：
M. Trujillo
植物U-box型E3泛素连接酶（PUBs）在植物的免疫应答和非生物胁迫适应中发挥重要作用。首先与花粉自交不亲和性有关，它们的作用库已经发展到也包括发育过程的调节。值得注意的是，新的研究为它们的作用模式提供了线索，强调了保守的PUB激酶模块的存在，并提出了与G蛋白信号传导的新联系，将PUB置于主要信号传导枢纽的十字路口。通过相互作用和/或靶向膜蛋白，以及通过最近报道的与磷脂的直接相互作用，与膜的频繁关联表明在控制囊泡运输及其货物中的一般功能。这篇评论旨在概述该领域最重要的进展，同时也试图确定PUB功能的共同主题。
Plant U-box type E3 ubiquitin ligases (PUBs) are well known for their functions in a variety of stress responses, including immune responses and the adaptation to abiotic stresses. First linked to pollen self-incompatibility, their repertoire of roles has grown to encompass also the regulation of developmental processes. Notably, new studies provide clues to their mode of action, underline the existence of conserved PUB-kinase modules, and suggest new links to G-protein signalling, placing PUBs at the crossroads of major signalling hubs. The frequent association with membranes, by interacting and/or targeting membrane proteins, as well as through a recently reported direct interaction with phospholipids, indicates a general function in the control of vesicle transport and their cargoes. This review aims to give an overview of the most significant advances in the field, while also trying to identify common themes of PUB function.