CD46-induced human Treg enhance B-cell responses.
CD46-induced human Treg enhance B-cell responses.
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DOI：
10.1002/eji.200939392
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发表时间：
2009-11
影响因子：
5.4
通讯作者：
Kemper, Claudia
中科院分区：
文献类型：
--
作者：
Fuchs, Anja;Atkinson, John P.;Fremeaux-Bacchi, Veronique;Kemper, Claudia
调节性CD 4 + T细胞（TCD 4 + T细胞）是免疫应答的重要调节剂。不同类型的胸腺激素已根据它们是胸腺衍生的（天然胸腺激素）还是外周诱导的（适应性胸腺激素）而被鉴定。我们最近报道了一种适应性Treg表型，其可以通过CD 3和膜补体调节因子CD 46同时刺激人CD 4 + T细胞来诱导。这些补体诱导的Treg细胞（cTreg）通过高水平分泌IL-10有效抑制旁观者T细胞增殖。此外，cTreg表达颗粒酶B并对活化的效应T细胞表现出细胞毒性作用。在此，我们分析了cTreg在共培养系统中对B细胞功能的影响。我们发现cTreg增强B细胞抗体的产生。这种B细胞支持依赖于细胞/细胞接触以及来源于cTreg的IL-10。此外，我们表明，T细胞从一个CD 46缺陷的患者是不能促进B细胞的反应，而CD 46缺陷的B细胞没有内在缺陷的IG生产。这一发现可能与CD 46缺陷患者的一个子集，目前与常见的可变免疫缺陷（CVID）。因此，缺乏cTreg在优化B细胞应答中的功能可以解释为什么一些CD 46缺陷型患者发生CVID。
Regulatory CD4+ T cells (Tregs) are important modulators of the immune response. Different types of Tregs have been identified based on whether they are thymically derived (natural Tregs) or induced in the periphery (adaptive Tregs). We recently reported on an adaptive Treg phenotype that can be induced by the concomitant stimulation of human CD4+ T cells through CD3 and the membrane complement regulator CD46. These complement-induced Treg cells (cTreg) potently inhibit bystander T cell proliferation through high-level secretion of IL-10. In addition, cTreg express granzyme B and exhibit cytotoxic effects towards activated effector T cells. Here we analyzed the effect of cTreg on B cell functions in a co-culture system. We found that cTreg enhance B cell antibody production. This B cell support is dependent on cell/cell contact as well as cTreg-derived IL-10. In addition, we show that T cells from a CD46-deficient patient are not capable of promoting B cell responses, whereas CD46-deficient B cells have no intrinsic defect in Ig production. This finding may relate to a subset of CD46-deficient patients who present with common variable immunodeficiency (CVID). Thus, the lack of cTreg function in optimizing B cell responses could explain why some CD46-deficient patients develop CVID.
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影响因子：
15.3
作者：
Galibert, L;Burdin, N;deSaintVis, B;Garrone, P;VanKooten, C;Banchereau, J;Rousset, F
通讯作者：
Rousset, F
影响因子：
13.2
作者：
Couzi, Lionel;Contin-Bordes, Cecile;Fremeaux-Bacchi, Veronique
通讯作者：
Fremeaux-Bacchi, Veronique
影响因子：
32.4
作者：
Grossman, WJ;Verbsky, JW;Ley, TJ
通讯作者：
Ley, TJ
影响因子：
20.3
作者：
Levings, MK;Gregori, S;Roncarolo, MG
通讯作者：
Roncarolo, MG
影响因子：
4.4
作者：
Gondek, DC;Lu, LF;Noelle, RJ
通讯作者：
Noelle, RJ