A case of newly diagnosed non-insulin-dependent diabetes associated with immediate-type allergy against human insulin.
A case of newly diagnosed non-insulin-dependent diabetes associated with immediate-type allergy against human insulin.
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一例新诊断的非胰岛素依赖型糖尿病与人胰岛素即刻型过敏有关。
DOI：
10.1159/000184354
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
T. Sawada
中科院分区：
文献类型：
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作者：
S. Yamagishi;T. Abe;T. Sawada
报告一例新诊断的非胰岛素依赖型糖尿病，对半合成人胰岛素即刻过敏。初次胰岛素治疗后 2 个月，她出现了速发型过敏。皮肤测试显示她对胰岛素本身过敏，但对添加剂不过敏。半合成人胰岛素的氨基酸序列与内源性天然胰岛素相同，而且患者之前没有接受过动物源胰岛素治疗，因此半合成制剂在皮下注射部位的结构变化可能具有抗原性。 H1 组胺阻滞剂显着减轻了皮肤对胰岛素的反应，她的血浆葡萄糖和糖化血红蛋白 A1c 得到了很好的控制。综上所述，我们经历了一位在初始胰岛素治疗时出现人胰岛素过敏的糖尿病患者，强调患者在开始胰岛素治疗时应考虑人胰岛素过敏的可能性。
A case of newly diagnosed non-insulin-dependent diabetes mellitus with immediate-type allergy against semisynthetic human insulin is reported. She experienced immediate-type allergy 2 months after initial insulin treatment. A skin test showed that she had allergy against the insulin itself but not the additives. The amino acid sequence of the semisynthetic human insulin was identical to that of endogenous native insulin and, moreover, the patient had not been treated with animal-derived insulin previously, so a structural change to the semisynthetic formulation at the injected subcutaneous site might have antigenicity. An H1 histamine blocker markedly diminished the skin reaction to insulin, and her plasma glucose and glycosylated hemoglobin AIc became well controlled. In summary, we experienced a diabetic patient with human insulin allergy at the time of initial insulin treatment, emphasizing that the possibility of human insulin allergy should be considered whenever a patient is started on insulin therapy.