Oxidative DNA damage in cancer patients: a cause or a consequence of the disease development?
Oxidative DNA damage in cancer patients: a cause or a consequence of the disease development?
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DOI：
10.1016/j.mrfmmm.2003.07.005
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发表时间：
2003-10-29
影响因子：
2.3
通讯作者：
Bialkowski, K
中科院分区：
文献类型：
--
作者：
Olinski, R;Gackowski, D;Bialkowski, K
在活细胞中存在多种氧化DNA损伤。这种类型的最著名的病变之一是8-氧代鸟嘌呤（8-oxoGua），已被证明具有致突变特性。本文讨论了抗氧化维生素和不稳定铁库对细胞DNA中8-oxoGua背景水平的影响，并描述了DNA和尿液中作为8-oxo-2 '-deoxyguanosine可能来源的游离核苷酸库的氧化损伤。8-oxoGua参与癌症的起源和/或进展进行审查。可以得出结论，严重的氧化应激表现为高水平的8-oxoGua在细胞DNA中，以及在癌症患者的尿液中是许多类型的癌症的发展的结果。虽然目前还不能直接回答有关氧化性DNA损伤参与癌症病因学的问题，但氧化性DNA碱基修饰可能是启动致癌作用的突变来源（即它们可能是导致该过程的因果因素）。(C)2003 Elsevier B. V.保留所有权利。
A wide variety of oxidative DNA lesions are present in living cells. One of the best known lesions of this type is 8-oxoguanine (8-oxoGua) which has been shown to have mutagenic properties. An influence of antioxidative vitamins and labile iron pool on the background level of 8-oxoGua in cellular DNA is discussed and oxidative damage to free nucleotide pool as a possible source of 8-oxo-2'-deoxyguanosine in DNA and urine is described. An involvement of 8-oxoGua in the origin and/or progression of cancer is reviewed. It is concluded that a severe oxidative stress manifested as a high level of 8-oxoGua in cellular DNA as well as in urine of cancer patients is a consequence of development of many types of cancer. Although at present it is impossible to answer directly the question concerning involvement of oxidative DNA damage in cancer etiology it is likely that oxidative DNA base modifications may serve as a source of mutations that initiate carcinogenesis (i.e. they may be causal factors responsible for the process). (C) 2003 Elsevier B.V. All rights reserved.