Circuit dynamics of the superior colliculus revealed by in vitro voltage imaging.
Circuit dynamics of the superior colliculus revealed by in vitro voltage imaging.
复制标题
体外电压成像揭示上丘的电路动力学。
DOI：
10.1111/j.1749-6632.2011.06166.x
复制
发表时间：
2011
影响因子：
5.2
通讯作者：
Basso,MicheleA
中科院分区：
文献类型：
--
作者：
Vokoun,CorinneR;Jackson,MeyerB;Basso,MicheleA
上级丘（SC）是众所周知的，其参与的感官刺激转化为运动指令。这种感觉运动的整合是通过整个SC中多个神经元连接的集体活动实现的。尽管如此，大多数SC研究集中在行为猴子的体内细胞外记录或低等哺乳动物的体外膜片钳记录上。在这里，我们讨论了体外电压成像技术的结果，在该技术中，啮齿动物SC回路中的群体活动被可视化，以弥合单细胞记录和整个动物行为之间的差距。电压成像技术的高时间和空间分辨率使我们能够可视化离散椎板刺激后的活动模式。无论是表面或中间层内的刺激显示招聘不同的SC电路。这些结果提供了深入了解电路动力学和神经元群体的基础行为。
The superior colliculus (SC) is well known for its involvement in the conversion of sensory stimuli into motor commands. This sensorimotor integration is made possible by the collective activity of multiple neuronal connections throughout the SC. Still, the majority of SC research focuses onin vivoextracellular recordings of behaving monkeys orin vitropatch‐clamp recordings from lower mammals. Here, we discuss the results of anin vitrovoltage‐imaging technique in which population activity across the rodent SC circuitry was visualized to bridge the gap between single‐cell recordings and whole‐animal behavior. The high temporal and spatial resolution of the voltage‐imaging technique allowed us to visualize patterns of activity following stimulation at discrete laminae. Stimulation within either the superficial or intermediate layer showed recruitment of disparate SC circuitry. These results provide insight into the circuit dynamics and neuronal populations that underlie behavior.