In vitro anti-human immunodeficiency virus activities of tumor necrosis factor-alpha and interferon-gamma.
In vitro anti-human immunodeficiency virus activities of tumor necrosis factor-alpha and interferon-gamma.
复制标题
肿瘤坏死因子-α和干扰素-γ的体外抗人类免疫缺陷病毒活性。
作者：
G. Wong;J. Krowka;D. Stites;D. Goeddel
用肿瘤坏死因子-α和干扰素-γ治疗细胞大大降低了它们对人类免疫缺陷病毒感染的易感性，并抑制了人类免疫缺陷病毒（HIV）mRNA、核心蛋白p24和感染性HIV的产生。联合治疗对HIV感染细胞具有细胞毒性，并降低慢性感染细胞中的HIV RNA水平。
Treatment of cells with tumor necrosis factor-alpha and interferon-gamma greatly reduces their susceptibility to infection with human immunodeficiency virus and suppresses the production of human immunodeficiency virus (HIV) mRNA, core protein p24, and infectious HIV. The combination treatment is cytotoxic for HIV-infected cells and reduces HIV RNA levels in chronically infected cells.