PHYSIOLOGICAL-RESPONSES OF HUMAN ADULTS TO FOODS CONTAINING PHOSPHATE ADDITIVES
PHYSIOLOGICAL-RESPONSES OF HUMAN ADULTS TO FOODS CONTAINING PHOSPHATE ADDITIVES
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DOI：
10.1093/jn/107.1.42
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发表时间：
1977-01-01
影响因子：
4.2
通讯作者：
SCHMIDT, GR
中科院分区：
文献类型：
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作者：
BELL, RR;DRAPER, HH;SCHMIDT, GR
进行了一项实验，以评估富含含磷酸盐添加剂的食物的饮食的生理效应。在为期4周的控制期间，8名成年人被喂食不含磷酸盐添加剂的平衡饮食，每天提供约95 g蛋白质、0.7 g Ca和1.0 g P。在随后的4周期间，含有磷酸盐添加剂的食品被替换为没有添加磷酸盐的对应食品。该饮食含有0.7 g Ca和2.1 g P/天。引入含有磷酸盐添加剂的食物与肠道不适、软便或轻度腹泻有关。这些症状在6名受试者中消退，但在其他2名受试者中在整个实验期间间歇性发生。高磷饮食引起血清磷和尿磷升高，血清钙和尿钙降低。8例受试者中有6例尿羟脯氨酸排泄增加，环[c]AMP排泄升高。这些变化与喂食高磷饮食的实验动物中观察到的变化相似，这些变化是由于甲状旁腺活性增强（继发性甲状旁腺功能亢进）所致。磷酸盐食品添加剂的使用进行了讨论，其可能的刺激成人骨吸收的影响。
An experiment was conducted to assess the physiological effects of a diet rich in foods containing phosphate additives. During a 4 wk control period, 8 adults were fed a balanced diet free of phosphate additives providing approximately 95 g protein, 0.7 g Ca and 1.0 g P/day. During a subsequent 4 wk period, food items containing phosphate additives were substituted for counterpart items devoid of added phosphates. This diet contained 0.7 g Ca and 2.1 g P/day. The introduction of foods containing phosphate additives was associated with intestinal distress, soft stools or mild diarrhea. These symptoms subsided in 6 subjects but occurred intermittently throughout the experimental period in the other 2 subjects. The high-P diet induced increases in serum P and urinary P and decreases in serum Ca and urinary Ca. Hydroxyproline excretion in the urine was increased and cyclic[c]AMP excretion was elevated in 6 of the 8 subjects. These changes are analogous to those seen in experimental animals fed high-P diets which were shown to be due to enhanced parathyroid activity (secondary hyperparathyroidism). The use of phosphate food additives is discussed with respect to their possible stimulating effect on adult bone resorption.