[Hyperlipidemia and coronary heart disease].
[Hyperlipidemia and coronary heart disease].
复制标题
高脂血症与冠心病[M].
DOI：
--
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
F. Leisch
中科院分区：
文献类型：
--
作者：
W. Schützenberger;W. Harringer;F. Leisch
血清总胆固醇水平大于200毫克/分升或低密度脂蛋白胆固醇水平大于155毫克/分升（135毫克/分升）与冠心病发病率之间的关系已得到充分证实。相反，高密度脂蛋白胆固醇水平与心脏性死亡和非致死性心肌梗死的频率呈反比关系。甘油三酯水平升高（大于200毫克）似乎也可能是另一个危险因素。随后大量患者和长期观察的研究证明，脂肪调节饮食或高脂血症药物治疗可降低冠心病发病率和死亡率，冠状动脉事件的减少分别与总胆固醇或低密度脂蛋白胆固醇的降低程度直接相关。这些知识使临床医生能够识别冠心病高危人群，并根据欧洲动脉粥样硬化协会的建议开始有效的个体化治疗。
The relationships between total serum cholesterol levels greater than 200 mg/dl or LDL-cholesterol levels greater than 155 mg/dl (135 mg/dl) and the incidence of coronary heart disease is well established. In contrast an inverse relationship could be shown between HDL-cholesterol levels and the frequency of cardiac death and non fatal myocardial infarction. It also seems to be possible that elevated triglyceride levels (greater than 200 mg) may represent an additional risk factor. Subsequent studies with a large number of patients and longterm observation proved, that fat-modified diets or drug treatment of hyperlipidemia results in a reduction of morbidity and mortality due to coronary heart disease, whereby the reduction of coronary events correlates directly to the degree of reduction of total cholesterol or LDL-cholesterol, respectively. This knowledge allows the clinician to identify persons at high risk for coronary heart disease and to start effective individual therapy in accordance with the recommendations of the European Atherosclerosis Society.