Interhemispheric functional interactions between the subthalamic nuclei of patients with Parkinson's disease
Interhemispheric functional interactions between the subthalamic nuclei of patients with Parkinson's disease
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DOI：
10.1111/ejn.12686
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发表时间：
2014-10-01
影响因子：
3.4
通讯作者：
Nikulin, V. V.
中科院分区：
文献类型：
--
作者：
Hohlefeld, F. U.;Huchzermeyer, C.;Nikulin, V. V.
帕金森病（PD）的特征是皮质-基底神经节网络中广泛的神经相互作用，主要是在β振荡中。10-30Hz)，正如先前在局部场电位记录（LFPs）中左旋多巴调节的双侧丘脑下核（STN）之间的半球间相干性所表明的那样。然而，由于体积传导的混杂效应，是否存在真正的“半球间皮层下一致性”仍然是一个悬而未决的问题。为了解决这个问题，我们利用了相干的虚部（iCOH），与标准相干相比，它不受体积传导的影响。记录8例PD患者左旋多巴给药前后清醒休息时的lfp。我们证明了在10-20和21-30Hz振荡中双边STN之间的真正一致性，正如非零iCOH所揭示的那样。至关重要的是，在10-20Hz振荡中，iCOH的增加与OFF药物治疗条件下患者运动症状的恶化正相关，而标准一致性的情况并非如此。此外，在21-30Hz的振荡中，左旋多巴给药后患者iCOH增加。这些结果表明，在STN-LFP中存在低β振荡和高β振荡的功能区别，这与先前的研究一致。此外，观察到的双侧STN之间的功能耦合可能有助于理解单侧深部脑刺激的双侧效应。总之，目前的研究结果表明，延迟神经相互作用对半球间一致性的重要贡献，以及双侧STN之间的远距离神经相互作用与PD运动症状的临床相关性。
Parkinson's disease (PD) is characterized by widespread neural interactions in cortico-basal-ganglia networks primarily in beta oscillations (approx. 10-30Hz), as suggested by previous findings of levodopa-modulated interhemispheric coherence between the bilateral subthalamic nuclei (STN) in local field potential recordings (LFPs). However, due to confounding effects of volume conduction the existence of genuine' interhemispheric subcortical coherence remains an open question. To address this issue we utilized the imaginary part of coherency (iCOH) which, in contrast to the standard coherence, is not susceptible to volume conduction. LFPs were recorded from eight patients with PD during wakeful rest before and after levodopa administration. We demonstrated genuine coherence between the bilateral STN in both 10-20 and 21-30Hz oscillations, as revealed by a non-zero iCOH. Crucially, increased iCOH in 10-20Hz oscillations positively correlated with the worsening of motor symptoms in the OFF medication condition across patients, which was not the case for standard coherence. Furthermore, across patients iCOH was increased after levodopa administration in 21-30Hz oscillations. These results suggest a functional distinction between low and high beta oscillations in STN-LFP in line with previous studies. Furthermore, the observed functional coupling between the bilateral STN might contribute to the understanding of bilateral effects of unilateral deep brain stimulation. In conclusion, the present results imply a significant contribution of time-delayed neural interactions to interhemispheric coherence, and the clinical relevance of long-distance neural interactions between bilateral STN for motor symptoms in PD.