EXPRESSION OF THE CLONED TOXIC SHOCK SYNDROME TOXIN-1 GENE (TST) INVIVO WITH A RABBIT UTERINE MODEL
EXPRESSION OF THE CLONED TOXIC SHOCK SYNDROME TOXIN-1 GENE (TST) INVIVO WITH A RABBIT UTERINE MODEL
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DOI：
10.1128/iai.50.1.304-309.1985
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发表时间：
1985-01-01
影响因子：
3.1
通讯作者：
NOVICK, RP
中科院分区：
文献类型：
--
作者：
DEAZAVEDO, JCS;FOSTER, TJ;NOVICK, RP
Toxic shock syndrome (TSS) toxin 1 (TSST1) is produced by strains of Staphylococcus aureus associated with TSS. Purified TSST1 induces in rabbits a shock-like illness with many features similar to TSS in humans. These symptoms were also induced by TSST1-producing bacteria in diffusion chambers implanted in the rabbit uterus. Naturally occurring TSST1+ strains and a TSST1- strain harboring a pE194-derived plasmid carrying the cloned TSST1 determinant tst gave the same symptoms. TSST1- strains and a TSST1- strain carrying a pE194-tst plasmid with a deletion of the tst gene had no effect in rabbits. The results with the plasmid-carrying TSST1+ and TSST1- strains, which were isogenic apart from tst, show that the toxin is responsible for the illness in rabbits and suggest that it is a major factor in the pathogenesis of TSS.
